Methylglyoxal 丙酮醛

CAS 78-98-8 MFCD00006960

化学结构图

78-98-8
SMILES: CC(=O)C=O

化学属性

Mol. FormulaC3H4O2
Mol. Weight72.06
Density1.17
Refractive indexn20/D 1.41
TSCAYes
Melting Point25 °C
Boiling Point72 °C at 760 mmHg
Solubility>=10 G/100 ML AT 17 ºC
Stability对湿度敏感
Appearance 具有刺激气味的黄色粘稠状液体。
pH:A

别名和识别编码

Chemical NamePyruvaldehyde (35% w/w aqueous)
Synonym Pyruvic aldehyde {LY} Pyruvic aldehyde {} {LY} Pyruvic aldehyde {} {} {LY} Pyruvic aldehyde {} {} {} {LY} Pyruvic aldehyde {} {} {} {} {LY} Pyruvic aldehyde {} {} {} {} {} {LY} Pyruvic aldehyde {} {} {} {} {} {} {LY} Pyruvic aldehyde {} {} {} {} {} {} {} {LY} Pyruvic aldehyde {} {} {} {} {} {} {} {} {LY} Pyruvic aldehyde {} {} {} {} {} {} {} {} {} {LY} Pyruvic aldehyde {} {} {} {} {} {} {} {} {} {} {LY} Pyruvic aldehyde {} {} {} {} {} {} {} {} {} {} {} {LY} Pyruvic aldehyde {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyruvic aldehyde {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyruvic aldehyde {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyruvic aldehyde {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyruvic aldehyde {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyruvic aldehyde {} {} {} {} {} {} {} {} {} {} {} {} {}
CAS Number78-98-8
EC Number201-164-8
Beilstein Registry Number906750
MDL NumberMFCD00006960
PubChem Substance ID880
Merck Number14,6081
Chemical Name Translation丙酮醛
Wiswesser Line NotationVHV1
LabNetwork Molecule IDLN00010096
Canonical SMILESCC(C=O)=O
InChIInChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3
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分类

  • {Chemicalbook} 食品添加剂: 食用香料(增香剂): 天然等同香料和人造香
  • {SNA} Aldehydes,
  • {SNA} Alphabetical Listings, Flavors and Fragrances, Halal Certified Products, O - Z, O-P
  • {SNA} Aldehydes, Building Blocks, C1 to C6, Carbonyl Compounds, Chemical Synthesis, Organic Building Blocks, Other Biochemical,

产品应用

  • 用作医药、农药中间体及生化试剂

相关文献及参考

  • Short: EINECS
  • Merck: 14,6081 Beilstein: 1,IV,3631
  • Merck: 14,6081
  • Short: II/14a
  • Short: III/38B

安全信息

Signal word
GHS Symbol
WGK Germany3
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
Risk Statements
  • R36 Irritating to eyes 刺激眼睛
  • R22 Harmful if swallowed 吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P203
  • P234 Keep only in original container. 只保留在原来的容器中。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P301+P312
  • P301+P317
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P305+P354+P338
  • P308+P313
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P317
  • P318
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P332+P317
  • P333+P313
  • P337+P313
  • P337+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P362+P364
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P390 Absorb spillage to prevent material damage. 吸收溢出物,防止重大损害。
  • P403+P233
  • P404 Store in a closed container. 贮存于密闭容器中。
  • P405 Store locked up. 上锁保管。
  • P406 Store in corrosive resistant/… container with a resistant inner liner. 存放在耐腐蚀/具有耐性的内衬容器。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H290 May be corrosive to metals 可能腐蚀金属。
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H318 Causes serious eye damage 严重伤害眼睛
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Storage condition Solution, -20°C, 2 years {LY} Solution, -20°C, 2 years {} {LY} Solution, -20°C, 2 years {} {} {LY} Solution, -20°C, 2 years {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {} {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {} {} {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {} {} {} {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {} {} {} {} {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {} {} {} {} {} {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Solution, -2
Hazard Codes Xn Xn,Xi
RTECSUZ0700000
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 179 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCISP* National Cancer Institute Screening Program Data Summary,
   Developmental Therapeutics Program. (Bethesda, MD 20205)
   Volume(issue)/page/year: JAN1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1165 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EESADV Ecotoxicology and Environmental Safety.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.1-    1977-  Volume(issue)/page/year:
   2,369,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 252 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CKFRAY Ceskoslovenska Farmacie.  (PNS-Ustredni Expedice a Dovoz Tisku,
   Kafkova 19, 160 00 Prague 6, Czechoslovakia)  V.1-    1952-
   Volume(issue)/page/year: 15,300,1966

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Ascites tumor
DOSE/DURATION           : 1480 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   27,1498,1967

TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 10 mmol/L
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-  Volume(issue)/page/year: 2,275,1987

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 15 mmol/L
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, UK) V.1-

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - guinea pig Cells - not otherwise specified
DOSE/DURATION           : 6600 umol/L
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   38,339,1982

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 500 umol/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/y

TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 300 mg/kg
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-

其他信息

  • FEMA:2969
  • MSDS 信息:Pyruvaldehyde(78-98-8).msds
  • 用途一:用作医药、农药中间体及生化试剂
  • Acros Organics:丙酮醛 Pyruvic aldehyde, 40 wt% solution in water(78-98-8)
  • 下游产品:丙酮酸 --> 2-丙烯基-3-甲基-4-羟基-2-环戊烯-1-酮 --> 炔丙菊酯 --> 2-喹喔啉甲醛 --> 2-甲基咪唑-4-磺酸 --> 2-甲基喹喔啉 --> 吡唑硫磷 --> 2-甲基吡嗪 --> 2,4-二甲基咪唑 --> 1,1-二甲氧基丙酮
  • Hazard Note:Irritant
  • 用途二:可作西咪替丁、乳酸、丙酮酸、止痛药、抗癌、抗高血压药、脱敏剂、化妆品等原料。
  • MOL 文件:78-98-8.mol
  • Alfa Aesar:丙酮醛,35%w/waq.Soln Pyruvic aldehyde, 35% w/w aq. soln(78-98-8)
  • 使用限量:FEMA(mg/kg):饮料、冷饮,1.0;糖果、焙烤制品,0.03~5.0。 适量为限(FDA,§172.515,2001)。
  • Sigma Aldrich:78-98-8(sigmaaldrich)
  • 丙酮醛价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30161280 丙酮醛 40% 100ml 412元 2010/06/21 175795000 丙酮醛 Pyruvic aldehyde , 40 wt% solution in water 500 GR 7198元 2010/06/21 175791000 丙酮醛 Pyruvic aldehyde , 40 wt% solution in water 6 x 100 GR 12564元
  • 水溶性≥10 g/100 mL ( 17℃ )
  • 毒性:GRAS(FEMA)。

系列性分类