1,1-Dimethylhydrazine 1,1-二甲基肼

CAS 57-14-7 MFCD00007628

化学结构图

57-14-7
SMILES: CN(C)N

化学属性

Mol. FormulaC2H8N2
Mol. Weight60.12
Refractive indexn20/D 1.4075(lit.)
Boiling Point60-62 °C(lit.)
Density0.79 g/mL at 20 °C(lit.)
Autoignition Point478 °F
Vapor Density1.94 (vs air)
Vapor Pressure103 mmHg ( 20 °C)
Flash Point-18 ºC
Melting Point-57.2 ºC
SolubilityMISCIBLE

别名和识别编码

Chemical NameHydrazine, 1,1-dimethyl-
Synonym (CH3)2NNH2 1,1-DIMETHYLHYDRAZINE 1,1-Dimethylhydrazin 1,1-Dimethylhydrazine 1,1-dimethyhydrazine 1,1-dimethyl 1,1-dimethyl-hydrazin 1,1-dimethyl-hydrazine 1,1-dimethylhydrazine 1,1-二甲基肼 1,1-二甲肼 1，1-二甲基肼 ASYM-DIMETHYLHYDRAZINE Dimazin Dimazine Dimethyl hydrazine(unsymmetrical) Dimethylhydrazin, asymmetrisch Dimethylhydrazine Hydrazine, N,N-dimethyl- N,N-DIMETHYLHYDRAZINE N,N-DIMETHYLHYDRAZINE(ASYM) N,N-Dimethylhydrazin (asym.) N,N-Dimethylhydrazine N,N-dimethyl-hydrazine N,N-dimethylhydrazine N,N-dimethylhydrazine (asym.) anhydrous N,N-二甲基肼 N1,N1-Dimethylhydrazin Niesymetryc
CAS Number57-14-7
PubChem Substance ID5976
EC Number200-316-0
Beilstein Registry Number0605261
MDL NumberMFCD00007628
Chemical Name Translation1,1-二甲基肼
Merck Number14,3247
Wiswesser Line NotationZN1&1
InChIInChI=1S/C2H8N2/c1-4(2)3/h3H2,1-2H3
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分类

  • {Chemicalbook} 农药中间体: 植物生长调节剂中间体
  • Building Blocks, Chemical Synthesis, Hydrazines, Nitrogen Compounds, Organic Building Blocks
  • {uni_hamburg} no charge; 1fragment
  • {SNA} Building Blocks, Chemical Synthesis, Hydrazines, Nitrogen Compounds, Organic Building Blocks

相关文献及参考

  • 1. Toth, B. Cancer Res. 35 , 3693, (1975) 摘要
  • 2. Kaneko, T.; Tahara, S.; Takabayashi, F. Biol. Pharm. Bull. 30(11) , 2052, (2007)
  • Merck 14 ,3247
  • Beil. 4 ,IV,3322
  • Fieser 1 ,289 / Fieser 2 ,154 / Fieser 3 ,117 / Fieser 5 ,254 / Fieser 6 ,223 / Fieser 7 ,126 / Fieser 8 ,192 / Fieser 9 ,184 / Fieser 12 ,205 / Fieser 14 ,149 / Fieser 16 ,145
  • Aldrich MSDS 1 , 777:D / Corp MSDS 1 (1), 1384:D / FT-IR 2 (1), 460:B / FT-IR 1 (1), 295:A / FT-NMR 1 (1), 471:A / IR-Spectra (3), 173:C / IR-Spectra (2), 156:B / NMR-Reference 2 (1), 253:C / RegBook 1 (1), 313:F / Sax 6 , 1166 / Structure Index 1 , 43:B:1 / Vapor Phase 3 , 378:D
  • Short: II/25B Title: Structure Data Of Free Polyatomic Molecules: Molecules containing One or Two Carbon Atoms Author: Graner, G.; Hirota, E.; Iijima, T.; Kuchitsu, K.; Ramsay, D.A.; Vogt, J.; Vogt, N. Editor: Kuchitsu, K. Source: Landolt-Börnstein, New Series Volume: II/25B Year: 1999 Keyword: Free Polyatomic Molecules; Carbon Atoms; Molecules ISBN: 3-540-63645-5 ISBN: 978-3-540-63645-8 Internet Resource: DOI:10.1007/b68834 RefComment: IX, 512 pages. Hardcover Abstract: Volume II/25 is a supplemented and revised edition of the preceding volumes II/7, II/15, II/21 and II/23 containing up to date information on inorganic and organic polyatomic molecules. All experimental methods for the determination of quantitative structural data of free molecules have been considered: microwave, infrared, Raman, electronic and photoelectron spectroscopy as well as electron diffraction. The data obtained by these methods have been critically evaluated and compiled. They are presented separately for each molecule, together with a schematic figure of the structure and the original literature.
  • Short: III/20a Title: Nuclear Quadrupole Resonance Spectroscop

安全信息

GHS Symbol
WGK Germany3
Hazard Codes F;T;N F,T,N
Hazard statements
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H301 Toxic if swallowed 吞食有毒
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H331 Toxic if inhaled 吸入中毒
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H350 May cause cancer 可能致癌
  • H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US)
RTECSMV2450000
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
  • P242 Use only non-sparking tools. 只能使用无火花工具。
  • P243 Take precautionary measures against static discharge. 采取预防措施，防止静电放电。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P301+P310
  • P301+P330+P331
  • P302+P352
  • P303+P361+P353
  • P304+P340
  • P305+P351+P338
  • P307+P311
  • P308+P313
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
  • P320 Specific treatment is urgent (see … on this label). 紧急具体治疗（见本标签上的）。
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P337+P313
  • P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P370+P378
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P403+P233
  • P403+P235
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Safety Statements
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
Risk Statements
  • R11 Highly flammable 非常易燃
  • R51/53
  • R45 May cause cancer 可能致癌
  • R23/25 Toxic by inhalation and if swallowed 吸入及吞食都有毒
  • R34 Causes burns 会导致灼伤
UN Number 1163 UN 1163 6.1/PG 1
Packing GroupI
Hazard Class6.1
Storage condition 2-8°C
Restrict 剧毒化学品
Warnings 危化品目录(2015) 危险化学品 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5880 mg/kg/42W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Vascular - tumors
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher informatio

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 288 mg/kg/8W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   42,337,1969

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 2686 mg/kg/72W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Peripheral Nerve and Sensation - peripheral nerve tumors
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   35,303,1

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 400 mg/kg/20W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Gastrointestinal - tumors
   Gastrointestinal - colon tumors
REFERENCE :
   SUFOAX Surgical Forum.  (American College of Surgeons, 55 E. Erie St.,
   Chicago, IL 60611) V.1-    1950-  Volume(issue)/page/year: 31,413,1980

TYPE

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 172 ppm/4H
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   AMIHAB AMA Archives of Industrial Health.  (Chicago, IL)  V.11-21, 1955-60.
   For publisher information, see AEHLAU.  Volume(issue)/page/year: 12,609,1955

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 122 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MEPAAX Medycyna Pracy.  Industrial Medicine.  (Ars-Polona, POB 1001, 00-068
   Warsaw 1, Poland) V.1-    1950-  Volume(issue)/page/year: 24,71,1973

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intracerebral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 27 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   14,1901,1965

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 392 ppm/4H
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   AMIHAB AMA Archives of Industrial Health.  (Chicago, IL)  V.11-21, 1955-60.
   For publisher information, see AEHLAU.  Volume(issue)/page/year: 12,609,1955

TYPE OF TEST            : LC50 - Lethal concentration,

{hazard

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - mouse Ascites tumor
DOSE/DURATION           : 900 umol/L
REFERENCE :
   JJATDK JAT, Journal of Applied Toxicology.  (John Wiley &

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Ascites tumor
DOSE/DURATION           : 1100 umol/L
REFERENCE :
   JJATDK JAT, Journal of Applied Toxicology.  (John Wiley & Sons Ltd., Baffins
   Lane, Chichester, W. Sussex PO19 1UD, UK)  V.1-    1981-
   Volume(issue)/page/year: 1,243,1981

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 42 umol/plate
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   41,1469,1981

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Rodent - mouse Liver
DOSE/DURATION           : 100 umol/L
REFERENCE :
   JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB
   211, 1000 AE Amsterdam, Netherlands)  V.76-    1985-
   Volume(issue)/page/year: 79,204,1988

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 167 umol/L
REFERENCE :
   PNASA6 Proceedings of the National Academy of Sciences of the United States
   of America.  (National Academy of Sciences, Printing & Pub. Office, 2101
   Constitution Ave., Washington, DC 20418) V.1-    1915-
   Volume(issue)/page/year: 80,7219,1983

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 300 umol/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 7,267,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 600 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(issue)/page/year: 13,125,1984

其他信息

  • 下游产品:萎蔫酸 --> 5-丁基吡啶-2-甲腈 --> 二甲基肼吡啶 --> 丁酰肼
  • 方法二:本品可以氨水、氯化胺和二甲胺为原料经反应合成制得。先将氨水和次氯酸钠分别送入一步反应器进行反应生成氯代胺，然后将氯代胺送入二步反应器与二甲胺水溶液进行合成，生成偏二甲肼水溶液，再将此合成液送入一系列精馏塔进一步蒸馏精馏，脱除过量的氨、二甲胺和偏腙，加碱提浓、脱气后，即得成品。
  • 灭火剂:干粉、干砂、二氧化碳、泡沫、1211灭火剂
  • 爆炸物危险特性:与空气混合可爆
  • 检测方法:GC,NMR
  • 蒸气压:103 mm Hg ( 20 °C)
  • 用途一:用作燃料添加剂及用于有机合成
  • 职业标准:TWA 1 毫克/ 立方米; STEL 0.25 毫克/ 立方米
  • 图谱信息:1,1-二甲基肼(57-14-7)核磁图( 13 CNMR) 1,1-二甲基肼(57-14-7)质谱(MS) 1,1-二甲基肼(57-14-7)Raman光谱 1,1-二甲基肼(57-14-7)红外图谱(IR1)
  • 外观性质:无色带有氨气味的液体, 具有吸湿性。
  • 类别:易燃液体
  • 可燃性危险特性:遇明火、高温、氧化剂易燃; 遇热分解有毒氧化氮气体
  • 敏感性:Hygroscopic
  • 用途三:该品用于生产植物生长调节剂，其苯酚盐可减少润滑盐的沉积现象。还可用于吸收酸性气体，也可用作高能原料。
  • 上游原料:次氯酸钠 --> 二甲胺 --> 氯酸钠 --> 次氯酸 --> 二苯甲酮腙 --> 二甲胺水溶液 --> 氯化胺
  • MOL 文件:57-14-7.mol
  • Sigma Aldrich:57-14-7(sigmaaldrich)
  • 急性毒性:口服- 大鼠 LD50: 122 毫克/ 公斤; 口服- 小鼠 LD50: 265 毫克/ 公斤
  • 毒性分级:高毒
  • 蒸气密度:1.94 (vs air)
  • 储运特性:库房通风低温干燥; 与氧化剂、酸类分开存放
  • 用途二:N，N-二甲基肼又称偏二甲基肼，是植物生长调节剂丁酰肼的中间体。
  • 海关编码:29280090
  • 方法一:其制备方法是以氨与次氯酸钠反应生成NH 2 Cl，然后与二甲胺反应即可得到产品。反应方程式：NH 3 +NaOCl→NH 2 Cl[HN(CH 3 ) 2 ]→H 2 NN(CH 3 ) 2
  • MSDS 信息:1,1-二甲基肼(57-14-7).msds

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Hydrazines - Nitrogen Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Hydrazines - Nitrogen Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Guanidines

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