CAS 106-47-8 MFCD00007835-4-Chloroaniline 对氯苯胺 -LabNovo

4-Chloroaniline 对氯苯胺

CAS 106-47-8 MFCD00007835

化学结构图

SMILES: Nc1ccc(Cl)cc1

化学属性

Mol. Formula	C6H6ClN
Mol. Weight	127.57
Boiling Point	-
Melting Point	68-71°C
Density	1.14
Flash Point	120°C
TSCA	Yes
Vapor Density	4.4 (vs air)
Vapor Pressure	0.15 mmHg ( 25 °C)
Solubility	溶于热水、多数有机溶剂。
Stability	对光敏感
Refractive index	1.5546

别名和识别编码

Chemical Name	4-Chloroaniline
CAS Number	106-47-8
Alfabeta Name	CHLOROBENZENAMINE 4-
MDL Number	-
Synonym	4-Chloroaniline {LY} 4-Chloroaniline 4-Chloroaniline(4-Chlorophenylamine) {} {LY} 4-Chloroaniline {} {} {LY} 4-Chloroaniline {} {} {} {LY} 4-Chloroaniline {} {} {} {} {LY} 4-Chloroaniline {} {} {} {} {} {LY} 4-Chloroaniline {} {} {} {} {} {} {LY} 4-Chloroaniline {} {} {} {} {} {} {} {LY} 4-Chloroaniline {} {} {} {} {} {} {} {} {LY} 4-Chloroaniline {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {LY} 4-Chloroaniline {} {} {} {} {} {} {} {} {} {} {LY} 4-Chloroaniline {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Chloroaniline {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Chloroaniline {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Chloroaniline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Chloroaniline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Chloroaniline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-C
PubChem Substance ID	87565294
EC Number	203-401-0
Beilstein Registry Number	471359
Reaxys-RN	471359
Merck Number	2118
Chemical Name Translation	对氯苯胺
Wiswesser Line Notation	ZR DG
LabNetwork Molecule ID	LN00175027
InChI	InChI=1S/C6H6ClN/c7-5-1-3-6(8)4-2-5/h1-4H,8H2
Canonical SMILES	NC1=CC=C(Cl)C=C1

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分类

{SNA} 2002/61/EC, APIs & Metaboli
{SNA} 2002/61/EC,
{SNA} Amines, Building Blocks, C6, Chemical Synthesis, Nitrogen Compounds, Organic Building Blocks
{SNA} 2002/61/EC, APIs & Metabolites, APIs (Active Pharmaceutical Ingredients) & Metabolites, Additional Standards, All alphabetical sorted, Amines, Analytical Standards, Antibiotics Standards, Aromatics, Aryl Amines MAK III, Category 2, C, Chemical Class, Chlorhexidine Metabolite, Chromatography, Colorant Standards, Colors, European Community: ISO, DIN and DL 152, Food and Cosmetic Compone

产品应用

本品用作偶氮染料及制造色酚AS-LB的中间体,也用作利眠宁,非那酊等医药中间体。

安全信息

Warnings 危化品目录(2015) IRRITANT

GHS Symbol

WGK Germany3

Hazard statements

H301+H311
H350 May cause cancer 可能致癌
H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
H317 May cause an allergic skin reaction 可能导致皮肤过敏
H301+H311+H331
H331 Toxic if inhaled 吸入中毒
H311 Toxic in contact with skin 皮肤接触中毒
H301 Toxic if swallowed 吞食有毒

Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Hazard Codes T,N T,N,F F,T

RTECSBX0700000

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P301+P310+P330
P308+P313
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P201 Obtain special instructions before use. 使用前获取专门指示。
P403+P233
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P305+P351+P338
P501 Dispose of contents/container to..… 处理内容物/容器.....
P302+P350
P337+P313
P273 Avoid release to the environment. 避免释放到环境中。
P301+P310
P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P304+P340+P312
P305+P351+P338+P337+P313
P308+P311
P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。

Signal word

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S7 Keep container tightly closed 保存在严格密闭容器中；
S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；

Risk Statements

R45 May cause cancer 可能致癌
R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
R50/53
R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

UN Number UN2018

Packing GroupII

Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

Hazard Class6.1

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 14 gm/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Vascular - tumors
   Blood - tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-189,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5150 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   29,119,1991

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 9270 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Endocrine - tumors
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   29,119,1991

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 328 gm/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Vascular - tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-189,1979

TYPE OF TEST            : TD - Toxic do

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TSCAT* Office of Toxic Substances Report.  (U.S. Environmental Protection
   Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
   Volume(issue)/page/year: OTS 206512

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 350 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982  Volume(issue)/page/year: -,34,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - muscle weakness
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 32(7),13,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene.  (Berlin, Ger.)
   V.1-18, 1930-61.  For publisher information, see IAEHDW.
   V

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Mold - Aspergillus nidulans
DOSE/DURATION           : 200 mg/L
REFERENCE :
   CJMIAZ Canadian Journal of Microbiology.  (National Research Council of
   Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.1- 
     1954-  Volume(issue)/page/year: 16,369,1970

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 5 mg/L
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 62,873,1979

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 1520 umol/L
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-  Volume(issue)/page/year: 3,193,1988

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 5 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 97,359,1982

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 15600 ug/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - rat Embryo
DOSE/DURATION           : 14500 ng/plate
REFERENCE :
   JJATDK JAT, Journal of Applied Toxicology.  (John Wiley & Sons Ltd., Baffins
   Lane, Chichester, W. Sussex PO19 1UD, UK)  V.1-    1981-
   Volume(issue)/page/year: 1,190,1981

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Restrict 危险品

其他信息

对光、空气敏感。易溶于乙醇、乙醚、丙酮和二硫化碳，溶于热水、多数有机溶剂。
灭火剂:二氧化碳、泡沫、干粉、雾状水
用途四:对氯苯胺是除草剂莎稗磷，杀虫剂灭幼脲和植物生长调节剂抗倒胺
用途六:本品用作偶氮染料及制造色酚AS-LB的中间体,也用作利眠宁,非那酊等医药中间体。
用途五:用作偶氮染料及制造色酚AS-LB的中间体。也用作医药（如利眠宁、非那酊）、农药的中间体。还可用于生产彩色电影胶片的成色剂。目前，我国染料工业约消费对氯苯胺350t，其中色酚AS-LB约需对氯苯胺160t，有机颜料永固黄约60t、对氯吡唑酮约需80t。在医药工业中，利眠宁等药品产量每年在15-20t之间，生产这些药品约需对氯苯胺150t。1991年我国对氯苯胺出口量仅10t。
用途一:用作染料中间体
急性毒性:口服-大鼠 LD50: 300 毫克/公斤; 口服-小鼠LD50: 100 毫克/公斤
方法二:其制备方法是对硝基氯苯进行还原得到对氯苯胺，有铁粉还原、加氢还原和锌粉还原等几种方法。铁粉还原将对氯硝基苯、水和铁屑混合并加热至 95℃，对氯硝基苯完全溶化后滴加浓盐酸，调节滴加速度，使温度保持在25℃，滴加完毕后继续反应25h，冷却，加入过量氢氧化钠，使溶液呈碱性，蒸馏油层即得产品。加氢还原法将对氯硝基苯和乙醇按质量比1∶1.5混合，加入兰尼镍 (由100目镍铝二元合金制得)作催化剂，于温度为 50～70℃、压力 2.94～3.43 MPa、介质 pH
所属类别二:农药中间体: 杀虫剂中间体: 苯甲酰脲类杀虫剂
常规方法:采用铁桶包装，每桶净重200kg。贮存于阴凉、通风处，防潮、防火。按有毒危险品规定贮运。
防护措施:对人体的血液系统和神经系统有毒害作用。中毒后会引起肝肿、肝痛、记忆力衰退
方法二:其制备方法是对硝基氯苯进行还原得到对氯苯胺，有铁粉还原、加氢还原和锌粉还原等几种方法。铁粉还原将对氯硝基苯、水和铁屑混合并加热至 95℃，对氯硝基苯完全溶化后滴加浓盐酸，调节滴加速度，使温度保持在25℃，滴加完毕后继续反应25h，冷却，加入过量氢氧化钠，使溶液呈碱性，蒸馏油层即得产品。加氢还原法将对氯硝基苯和乙醇按质量比1∶1.5混合，加入兰尼镍 (由100目镍铝二元合金制得)作催化剂，于温度为 50～70℃、压力 2.94～3.43 MPa、介质 pH=5～6 的条件下，通氢气反应 2h，所得粗品在常压下蒸出乙醇和部分水，再减压蒸馏即得成品。此外，也有将对氯硝基苯与锌粉在乙酸介质中进行还原，可以较高收率得到对氯苯胺，但锌粉价格较高。
{Chemi
{Ch
类别:有毒物品
图谱信息:4-氯苯胺(106-47-8)质谱(MS) 4-氯苯胺(106-47-8)红外图谱(IR1) 4-氯苯胺(106-47-8)Raman光谱 4-氯苯胺(106-47-8)红外图谱(IR2) 4-氯苯胺(106-47-8)红外图谱(IR3) 4-
下游产品:2-氨基-5-氯二苯甲酮 --> 2,6-二氯苯并噻唑 --> 灭幼脲 --> 津奥啉 --> 洛开酰胺 --> 3-氯苯酚 --> 氟胺安定盐酸盐 --> 莎稗磷 --> 替尼达普 --> 依法韦仑 --> 硝西泮 --> 5-氨基-1-(4-氯苯基)-4-氰基-1H-吡唑 --> 6-氯-2-甲基喹啉 --> 氟脲杀 --> N-(4-氯苯基)-1-(1-甲基乙基)-4-哌啶胺 --> 4-氯-N-[1-(1-甲基乙基)-4-亚哌啶基]苯胺 --> 2-氨基-5-氯-2'-氟二苯甲酮 --> 1-(4-氯苯基)哌嗪 --> 2-氨基-5-氯-二苯甲醇 --> 对氯苯异氰酸酯 --> 色酚 AS-E --> 缩聚法合成的聚苯胺 --> 4-氯苯肼 --> 4-氯苯胺-2-磺酸 -
刺激数据:皮肤-兔 500 毫克/24小时轻度; 眼睛-兔 0.25 毫克/24小时重度
MOL 文件:106-47-8.mol
用途二:是偶氮染料及色酚AS-LB的中间体，也是医药利眠宁、非那西丁及农药的原料，还用于制彩色胶片成色剂
{C

4-Chloroaniline 对氯苯胺

CAS 106-47-8 MFCD00007835

化学结构图

化学属性

别名和识别编码

分类

产品应用

相关文献及参考

安全信息

其他信息

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化学结构图

化学属性

别名和识别编码

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产品应用

相关文献及参考

安全信息

其他信息

系列性分类

相关产品推荐

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