4-Chloro-2-Methylaniline 4-氯-2-甲基苯胺

CAS 95-69-2 MFCD00007842

化学结构图

95-69-2
SMILES: Cc1cc(Cl)ccc1N

化学属性

Mol. FormulaC7H8ClN
Mol. Weight141.60
Boiling Point241°C at 760 mmHg
Melting Point24-27°C
Refractive indexn20/D 1.583(lit.)
Density1.19
Flash Point99.44°C

别名和识别编码

Chemical Name4-Chloro-2-Methylaniline
CAS Number95-69-2
Alfabeta NameCHLOROMETHYLANILINE 42---
MDL NumberMFCD00007842
Synonym 4-Chloro-2-methylaniline {LY} 4-Chloro-2-methylaniline {} {LY} 4-Chloro-2-methylaniline {} {} {LY} 4-Chloro-2-methylaniline {} {} {} {LY} 4-Chloro-2-methylaniline {} {} {} {} {LY} 4-Chloro-2-methylaniline {} {} {} {} {} {LY} 4-Chloro-2-methylaniline {} {} {} {} {} {} {LY} 4-Chloro-2-methylaniline {} {} {} {} {} {} {} {LY} 4-Chloro-2-methylaniline {} {} {} {} {} {} {} {} {LY} 4-Chloro-2-methylaniline {} {} {} {} {} {} {} {} {} {LY} 4-Chloro-2-methylaniline {} {} {} {} {} {} {} {} {} {} {LY} 4-Chloro-2-methylaniline {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Chloro-2-methylaniline {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Chloro-2-methylaniline {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Chloro-2-methylaniline {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Chloro-2-methylaniline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Chloro-2-methylaniline {} {} {} {} {} {} {}
PubChem Substance ID87562256
EC Number202-441-6
Beilstein Registry Number12(4)1796
Reaxys-RN878505
Chemical Name Translation4-氯-2-甲基苯胺
Wiswesser Line NotationZR DG B1
LabNetwork Molecule IDLN00008624
InChIInChI=1S/C7H8ClN/c1-5-4-6(8)2-3-7(5)9/h2-4H,9H2,1H3
Canonical SMILESC1=C(Cl)C=CC(=C1C)N
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分类

  • {SNA} 2002/61/EC, Alphabetical Index of Analytical Standards, Chemical Class, Method and Regulation Specific, All alphabetical sorted, Alpha Sort, Analytical Standards, Analytical/Chromatography, Aryl Amines MAK III, Category 1, C, CH, Chloro, Chromatography, Colors, Environmental Standards, European Community: ISO, DIN and DL 152, Halogenated, Life Sciences Standards,
  • Amines, Building Blocks, C7, Chemical Synthesis, Nitrogen Compounds, Organic Building Blocks
  • {SNA} 2002/61/EC, Additional Standards,

产品应用

  • 农药、医药和染料的重要中间体。

相关文献及参考

  • Beilstein:12(4)1796
  • Short: EINECS
  • Short: III/20b

安全信息

Warnings TOXIC
GHS Symbol
WGK Germany3
Hazard statements
  • H302+H312
  • H331 Toxic if inhaled 吸入中毒
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H301 Toxic if swallowed 吞食有毒
  • H350 May cause cancer 可能致癌
  • H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Hazard Codes T,N
RTECSXU5000000
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P308+P313
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P301+P312+P330
  • P302+P350
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P301+P310
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P308+P311
  • P405 Store locked up. 上锁保管。
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P302+P352+P312+P362+P364
Signal word
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
Risk Statements
  • R45 May cause cancer 可能致癌
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
  • R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
  • R50/53
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
UN Number UN 2239 6.1/PG 3 2239
Packing GroupIII
Storage condition 2-8°C, protect from light {LY} 2-8°C, protect from light 2-8℃保存 {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light
Hazard Class6.1 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1058 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NNGADV Nippon Noyaku Gakkaishi.  Journal of the Pesticide Science Society of
   Japan.  (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
   Japan)  V.1-    1976-  Volume(issue)/page/year: 1,301,1976

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 310 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Gastrointestinal - nausea or vomiting
   Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
   AHBAAM Archiv fuer Hygiene und Bakteriologie.  (Munich, Fed. Rep. Ger.)
   V.101-154, 1929-71.  For publisher information, see ZHPMAT.
   Volume(issue)/page/year: 110,12,1933

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - wild bird species
DOSE/DURATION           : 75 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AECTCV Archives of Environmental Contamination and Toxicology.
   (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
   070944)  V.1-    1973-  Volume(issue)/page/year: 12,355,1983

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 200 nmol/plate
REFERENCE :
   JAFCAU Journal of Agricultural and Food Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
   20037)  V.1-    1953-  Volume(issue)/page/year: 34,157

TYPE OF TEST            : DNA repair
TEST SYSTEM             : B

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   BECTA6 Bulletin of Environmental Contamination and Toxicology.
   (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
   07094)  V.1-    1966-  Volume(issue)/page/year: 11,184,1974

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 200 nmol/plate
REFERENCE :
   JAFCAU Journal of Agricultural and Food Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB 57136, West End S

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 400 ug/plate
REFERENCE :
   JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food
   Contaminants, and Agricultural Wastes.  (Marcel Dekker, 270 Madison Ave.,
   New York, NY 10016)  V.B11-    1976-  Volume(issue)/page/year: 19,95,1984

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 2 gm/disc
REFERENCE :
   JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food
   Contaminants, and Agricultural Wastes.  (Marcel Dekker, 270 Madison Ave.,
   New York, NY 10016)  V.B11-    1976-  Volume(issue)/page/year: 19,95,1984

其他信息

  • 4-氯-2-甲基苯胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 A0704 4-氯-2-甲基苯胺 4-Chloro-2-methylaniline 25G 504元 2014/06/02 A0704 4-氯-2-甲基苯胺 4-Chloro-2-methylaniline 500G 3830元 2010/06/21 109371000 4-氯-2-甲基苯胺 4-Chloro-2-methylaniline 98% 100 GR 1759元
  • 用途二:农药、医药和染料的重要中间体。
  • TCI Shanghai:4-氯-2-甲基苯胺 2-Amino-5-chlorotoluene,>;95.0%(GC)(95-69-2)
  • Sigma Aldrich:95-69-2(sigmaaldrich)
  • 下游产品:4-氯-2-甲基苯甲酸 --> 灭虫隆 --> 4-氯-2-甲基苯基异硫氰酸酯
  • 外观性质:片状结晶至棕色液体。
  • 上游原料:甘氨酸 --> 苯甲酰氯 --> 邻甲基苯胺
  • 方法一:由邻甲苯胺经氯化而得。可有多种氯化方法。邻甲苯胺盐酸盐以氯苯为溶剂，在50-60℃通氯反应可得4-氯邻甲苯胺。也可先经酰化，再经氯化、水解而得。将邻甲苯胺和氯苯混合搅拌，滴加乙酐，在70-80℃搅拌反应1.5h，冷却，于50℃左右通氯，此时突然生成大量白色固体。停止通氯，加入浓盐酸和水，于95℃搅拌回流反应2h。冷至室温，加碱液中和而得。收率70%以上。另一种方法是在酸性介质中，将邻甲苯胺盐酸盐与氯化氢和氧气的混合气体（或氯气和氧气）反应。
  • 图谱信息:4-氯-2-甲基苯胺(95-69-2)红外图谱(IR3) 4-氯-2-甲基苯胺(95-69-2)红外图谱(IR2) 4-氯-2-甲基苯胺(95-69-2)核磁图( 13 CNMR) 4-氯-2-甲基苯胺(95-69-2)红外图谱(IR1) 4-氯-2-甲基苯胺(95-69-2)质谱(MS)
  • MOL 文件:95-69-2.mol
  • Acros Organics:4-氯-2-甲基苯胺 4-Chloro-2-methylaniline, 98%(95-69-2)
  • F:8-10
  • MSDS 信息:4-氯邻甲苯胺(95-69-2).msds
  • 用途一:用作农药、医药中间体

系列性分类

  1. C7 - Amines
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Halogenated Hydrocarbons 卤代烃
  5. Aryl 芳基卤代烃
  1. C10 to C11 - Amines
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Method Specific - Analytical Standards
  4. European Community: ISO, DIN and DL 152 - Method Specific
  5. 2002/61/EC - European Community: ISO, DIN and DL 152
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. C - Alphabetic
  5. CH - C
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Amines 胺
  6. C2 to C6

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