2,4-Dichloro-5-sulfamoylbenzoic acid 2,4-二氯-5-磺酰胺基苯甲酸

CAS 2736-23-4 MFCD00007931

化学结构图

2736-23-4
SMILES: NS(=O)(=O)c1cc(C(=O)O)c(Cl)cc1Cl

化学属性

Mol. FormulaC7H5Cl2NO4S
Mol. Weight270.08
Melting Point230-234°C
TSCANo
Solubility不溶
Density1.744
Boiling Point503.8°C at 760 mmHg
Flash Point258.5°C

别名和识别编码

Chemical Name2,4-Dichloro-5-sulfamoylbenzoic acid
CAS Number2736-23-4
Synonym 2,4-Dichloro-5-sulfamoylbenzoic acid {LY} 2,4-Dichloro-5-sulfamoylbenzoic acid 2,4-dichloro-5-sulfamoylbenzoic acid lasamide {} {LY} 2,4-Dichloro-5-sulfamoylbenzoic acid {} {} {LY} 2,4-Dichloro-5-sulfamoylbenzoic acid {} {} {} {LY} 2,4-Dichloro-5-sulfamoylbenzoic acid {} {} {} {} {LY} 2,4-Dichloro-5-sulfamoylbenzoic acid {} {} {} {} {} {LY} 2,4-Dichloro-5-sulfamoylbenzoic acid {} {} {} {} {} {} {LY} 2,4-Dichloro-5-sulfamoylbenzoic acid {} {} {} {} {} {} {} {LY} 2,4-Dichloro-5-sulfamoylbenzoic acid {} {} {} {} {} {} {} {} {LY} 2,4-Dichloro-5-sulfamoylbenzoic acid {} {} {} {} {} {} {} {} {} {LY} 2,4-Dichloro-5-sulfamoylbenzoic acid {} {} {} {} {} {} {} {} {} {} {LY} 2,4-Dichloro-5-sulfamoylbenzoic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2,4-Dichloro-5-sulfamoylbenzoic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2,4-Dichloro-5-sulfamoylbenzoic acid {} {} {} {} {} {} {} {}
MDL NumberMFCD00007931
EC Number220-358-3
PubChem Substance ID17655
Reaxys-RN2219046
Chemical Name Translation2,4-二氯-5-磺酰胺基苯甲酸
Wiswesser Line NotationZSWR BG DG EVQ
Beilstein Registry Number2219046
LabNetwork Molecule IDLN00226250
InChIInChI=1S/C7H5Cl2NO4S/c8-4-2-5(9)6(15(10,13)14)1-3(4)7(11)12/h1-2H,(H,11,12)(H2,10,13,14)
Canonical SMILESO=C(O)C1=CC(S(=O)(N)=O)=C(Cl)C=C1Cl
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分类

  • Aromatics
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Sulfur & Selenium Compounds
  • {SNA} Building Blocks, Chemical Synthesis, Organic Building Blocks, Sulfonamides/Sulfinamides, Sulfur Compounds

产品应用

  • 2,4-Dichloro-5-sulfamoylbenzoic Acid is a chlorinated sulfamoylbenzoic acid with diuretic acid.

相关文献及参考

  • Shani, J. et al.: Pharmacology, 26, 172 (1983); Lebedev, A.A. et al.: Khim.-Farm. Zhur., 19, 1205 (1985);

安全信息

RTECSDG8100000
Safety Statements
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Risk Statements
  • R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P350
  • P302+P352
  • P302+P352+P332+P313+P362+P364
  • P304+P340
  • P305+P351+P338
  • P305+P351+P338+P310
  • P305+P354+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P317
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P313
  • P332+P317
  • P337+P313
  • P337+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P362+P364
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Warning
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H318 Causes serious eye damage 严重伤害眼睛
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xi 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 15 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 19,697,1985

Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

其他信息

  • Alfa Aesar:2,4-二氯-5-氨磺酰基苯甲酸,98% 2,4-Dichloro-5-sulfamoylbenzoic acid, 98%(2736-23-4)
  • Acros Organics:2,4-二氯-5-磺酰胺基苯甲酸 2,4-Dichloro-5-sulfamoylbenzoic acid, 98%(2736-23-4)
  • MSDS 信息:5-(Aminosulfonyl)-2,4-dichlorobenzoic acid(2736-23-4).msds
  • MOL 文件:2736-23-4.mol
  • TCI Shanghai:2,4-二氯-5-磺酰胺苯甲酸 2,4-Dichloro-5-sulfamoylbenzoic Acid,>;96.0%(T)(2736-23-4)
  • 用途一:用于合成呋噻咪、速尿等药物
  • 用途二:速尿的中间体。
  • 2,4-二氯-5-磺酰胺基苯甲酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 D2541 2,4-二氯-5-磺酰胺苯甲酸 2,4-Dichloro-5-sulfamoylbenzoic Acid 25G 331元 2010/05/25 B24589 2,4-二氯-5-氨磺酰基苯甲酸, 98% 2,4-Dichloro-5-sulfamoylbenzoic acid, 98% 50g 351元 2010/05/25 B24589 2,4-二氯-5-氨磺酰基苯甲酸, 98% 2,4-Dichloro-5-sulfamoylbenzoic acid, 98% 250g 1025元
  • 下游产品:呋噻米
  • 图谱信息:2,4-二氯-5-磺酰胺基苯甲酸(2736-23-4)核磁图( 1 HNMR) 2,4-二氯-5-磺酰胺基苯甲酸(2736-23-4)质谱(MS) 2,4-二氯-5-磺酰胺基苯甲酸(2736-23-4)核磁图( 13 CNMR) 2,4-二氯-5-磺酰胺基苯甲酸(2736-23-4)红外图谱(IR1)
  • 上游原料:氯磺酸 --> 苯磺酰氯 --> 2,4-二氯苯甲酸
  • 方法一:用2,4-二氯苯甲酸以氯磺酸氯磺化，生成2,4-二氯-5-羧基苯磺酰氯，再以氨水胺化制得该品。

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Sulfur Compounds 硫化合物
  5. Sulfonamides/Sulfinamides - Sulfur Compounds

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