Benzamide 苯甲酰胺

CAS 55-21-0 MFCD00007968

化学结构图

55-21-0
SMILES: NC(=O)C1CCCCC1

化学属性

Mol. FormulaC7H7NO
Mol. Weight121
Melting Point127.0 to 130.0 deg-C
Density1.34
Flash Point180°(356°F)
TSCAYes
Boiling Point288
Solubility微溶于水。
Stability对湿度敏感

别名和识别编码

Chemical NameBenzamide
Synonym amidkyselinybenzoove {uni_hamburg} Benzamide-ring-13C6 BENZAMIDE 98+% Benzoylamid benzoic acid, amide BENZAMIDE, SUBLIMED, 99.5+% ai3-01031 Phenylcarboxyamide 苯酰胺 benzamide BENZAMIDE, SUBLIMED, ZONE-REFINED, 99.9% phenylcarboxamide Benzoylamide 苯甲酰胺, 98+% Benzamid 苯甲酰胺
MDL NumberMFCD00007968
CAS Number55-21-0
PubChem Substance ID87563343
EC Number200-227-7
Beilstein Registry Number9(3)1064
Merck Number1060
Chemical Name Translation苯甲酰胺
Reaxys-RN385876
Wiswesser Line NotationZVR
LabNetwork Molecule IDLN00192954
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分类

  • {SNA}
  • {SNA} Amides, B, Bioactive Small Molecules,
  • {SNA} Amides, Building Blocks, C2 to C7, Carbonyl Compounds, Chemical Synthesis, Organic Building Blocks
  • {SNA} Amides, Apoptosis and Cell Cycle, Building Blocks, C2 to C7, Carbonyl Compounds, Chemical Synthesis, Organic Building Blocks, PARP (Poly(ADP-Ribose) polymerase), PARP Inhibitors, 细胞信号转导和神经科学, 细胞生物学
  • Amides, Apoptosis and Cell Cycle, B, Bioactive Small Molecules, Building Blocks, Carbonyl Compounds, Cell Biology,

产品应用

  • 甘氨酸的测定。有机合成。其中优级纯用于生化研究,苯甲酰胺抑制聚ADP-核糖聚合酶poly(ADP-ribose) polymerase (PARP)。

相关文献及参考

  • Short: II/27B
  • Merck:14,1060
  • Short: II/2

安全信息

GHS Symbol
WGK Germany1
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xn
RTECSCU8700000
Precautionary statements
  • P301+P312+P330
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Warning
Safety Statements
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
Risk Statements
  • R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
  • R22 Harmful if swallowed 吞咽有害
Storage condition 密封保存。
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 781 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - muscle weakness
   Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
   APFRAD Annales Pharmaceutiques Francaises.  (SPPIF, B.P.22, F-41353 Vineuil,
   France)  V.1-    1943-  Volume(issue)/page/year: 48,23,1990

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1282 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - muscle weakness
   Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
   APFRAD Annales Pharmaceutiques Francaises.  (SPPIF, B.P.22, F-41353 Vineuil,
   France)  V.1-    1943-  Volume(issue)/page/year: 48,23,1990

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 28,335,1994

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1160 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   19,20,1971

TYPE OF TEST            : Micronucleus test
TEST SYSTEM             : Mammal - species unspecified Kidney
DOSE/DURATION           : 1000 ppm
REFERENCE :
   IJEBA6 Indian Journal of Experimental Biology.  (Publications & Information
   Director

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Mammal - species unspecified Kidney
DOSE/DURATION           : 1000 ppm/8H
REFERENCE :
   IJEBA6 Indian Journal of Experimental Biology.  (Publications & Information
   Directorate, CSIR, Hillside Rd., New Delhi 110 012, India)  V.1-    1963-
   Volume(issue)/page/year: 18,329,1980

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 126,

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 1650 umol/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 192,141,1987

TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 15500 ng/well
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 260,349,1991

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 126,63,1984

TYPE OF T

其他信息

  • 毒性分级:中毒
  • 可燃性危险特性:溶剂易燃
  • TCI Shanghai:苯甲酰胺(区域精制法精制,熔段数:20) Benzamide Zone Refined (number of passes:20)(55-21-0)
  • MSDS 信息:苯酰胺(55-21-0).msds
  • 灭火剂:干粉,泡沫,沙土,二氧化碳, 雾状水
  • 类别:有毒物品
  • 上游原料:苯甲酰氯 --> 搪玻璃反应锅 --> 碳酸铵
  • 用途四:甘氨酸的测定。有机合成。其中优级纯用于生化研究,苯甲酰胺抑制聚ADP-核糖聚合酶poly(ADP-ribose) polymerase (PARP)。
  • MOL 文件:55-21-0.mol
  • 储运特性:通风低温干燥
  • 苯甲酰胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30019924 苯甲酰胺;苯酰胺 25g 60元 2011/08/23 30079980 二十二烷酸 100g 1150.6元 2011/04/16 B0012 苯甲酰胺 Benzamide 500G 888元
  • 用途二:用于有机合成
  • 用途一:用于合成医药、染料等
  • 急性毒性:腹腔-大鼠 LD50: 781 毫克/公斤; 口服-小鼠 LD50: 1160 毫克/公斤
  • Sigma Aldrich:55-21-0(sigmaaldrich)
  • 1g溶于3.3ml吡啶、6ml乙醇、74ml水,溶于热水,溶于热苯,微溶于乙醚。溶于氨中形成少量苄腈。
  • 用途三:有机合成中间体。
  • 方法一:由苯甲酰氯与氨反应而得。先在搪玻璃反应锅内加入碳酸铵和相对密度0.905以下的氨水,搅拌,在40℃以下滴加苯甲酰氯。加完后再搅拌30min,至无苯甲酰氯气味为止。将粗品过滤、水洗、蒸馏水重结晶即得成品。
  • 外观性质:固体。
  • Acros Organics:苯甲酰胺 Benzamide, 99%(55-21-0)
  • 下游产品:苯甲腈 --> 氨茴酸甲酯 --> 氟氯菊酯 --> 4-乙酰氧基氮杂环丁酮 --> 2-(5-甲基-2-苯基1,3-氧杂醇-4-烷基)乙酸 --> 2-苯基吲哚 --> 溴替尼持 --> 4-哌啶酮 --> 2-[[3-[[(2,3-二氢-2-氧代-1H-苯并咪唑-5-基)氨基]甲酰]-2-羟基-1-萘]偶氮]苯甲酸丁酯 --> 颜料红 175 --> 盐酸普鲁卡因胺 --> 西沙必利 --> 苯甲酰异氰酸脂
  • 海关编码:29242995
  • Alfa Aesar:苯甲酰胺,98+% Benzamide, 98+%(55-21-0)

系列性分类


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