2-Ethoxybenzamide 2-乙氧基苯甲酰胺

CAS 938-73-8 MFCD00007977

化学结构图

938-73-8
SMILES: CCOc1ccccc1C(N)=O

化学属性

Mol. FormulaC9H11NO2
Mol. Weight165
Melting Point130.0 to 134.0 deg-C
TSCAYes
Solubility<0.1 G/100 ML AT 16 ºC
Appearance 白色或类白色结晶性粉末。熔点132-134℃。易溶于氯仿、乙醇、丙酮,难溶于水、乙醚。几乎无臭,无味。

别名和识别编码

Chemical Name2-Ethoxybenzamide
MDL NumberMFCD00007977
CAS Number938-73-8
PubChem Substance ID3282
EC Number213-346-4
Merck Number3731
Synonym O-ETHOXYBENZAMIDE 2-ETHOXYBENZAMIDE 2-Ethoxybenzenecarbonamide Katagrippe Ethenzamide; o-Ethoxybenzamide Ethylsalicylamide Protopyrin Benzamide, 2-ethoxy- Etenzamide Etosalicil 2-ethoxy-benzamid Eusal Ethosalicyl 乙水杨胺 Ethenzamide Lucamide Anovigam Trancalgyl Ethenzamid ETHENZAMIDE H.P. 209 Etamide Pirosolvina O-ETHYLSALICYLAMIDE 乙基水杨酰胺 乙基水杨胺 2-乙氧基苯甲酰胺 Ethbenzamide Etosalicyl ETHOXYBENZAMIDE 乙柳酰胺 邻乙氧基苯甲酰胺 o-Ethoxybenzamide 止痛灵 Benzamide, o-ethoxy- 2-ETHOXYBENZOYLAMIDE 2-Ethoxybenzamide Etocil
Chemical Name Translation2-乙氧基苯甲酰胺
Beilstein Registry Number10,93
Reaxys-RN2208582
Wiswesser Line NotationZVR BO2
InChIInChI=1S/C9H11NO2/c1-2-12-8-6-4-3-5-7(8)9(10)11/h3-6H,2H2,1H3,(H2,10,11)
LabNetwork Molecule IDLN01347706
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分类

  • {SNA} Amides, Building Blocks, C8 to C20+, Carbonyl Compounds, Chemical Synthesis, Organic Building Blocks
  • {SA} Amides, Building Blocks, C8 to C20+, Carbonyl Compounds, Chemical Synthesis, Organic Building Blocks

安全信息

WGK Germany2
RTECSCV4900000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
Signal word
Hazard statements
  • H303 May be harmfully swallowed 吞食可能有害
Precautionary statements
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 544 gm/kg/54W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 76,115,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2630 mg/kg
TOXIC EFFECTS :
   Behavioral - sleep
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 10,820,1960

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1500 mg/kg
TOXIC EFFECTS :
   Behavioral - sleep
   Cardiac - other changes
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 10,820,1960

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 4,872,1952

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 700 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 7,27,1952

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Embryo
DOSE/DURATION           : 16500 ug/L
REFERENCE :
   SNSHBT Senshokutai.  Chromosome.  (Sensyokutai Gakkai, Kaokusai Kirisutokyo
   Daigaku, Mitaka, Tokyo-to, Japan)  No.1-    1946-    Adopted new numbering
   in 1976.  Volume(issue)/page/year: (20),574,1980

TYPE OF TEST            : Morphological transformation
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 50400 mg/kg/6W
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 9,387,1988

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Fibroblast
DOSE/DURATION           : 500 mg/L
REFERENCE :
   ESKHA5 Eisei Shikenjo Hokoku.  Bulletin of the Institute of Hygienic
   Sciences.  (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
   Setagaya-ku, Tokyo 158, Japan)  V.1-    1886-  Volume(issue)/page/year:
   (96),55,1978

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 500 mg/L/48H
REFERENCE :
   GMCRDC Gann Monograph on Cancer Research.  (Plenum Pub. Corp., 233 Spring
   St., New York, NY 10013) No. 11-    1971-  Volume(issue)/page/year:
   27,95,1981

其他信息

  • 上游原料:溴乙烷 --> 氯乙烷 --> 固体氢氧化钠 --> 2-羟基苄胺
  • MSDS 信息:o-Ethoxybenzamide(938-73-8).msds
  • 方法一:由水杨酰胺(C7H7NO2,[65-45-2])经乙基化而得。将水杨酰胺、固体氢氧化钠、乙醇置于反就锅内,密闭升温至60-70℃,搅拌30min,冷却至30℃,加入溴乙烷,再密闭升温至80-100℃,压力不超过0.2MPa,反应3h。降至常压,pH应在8.5以上。趁热过滤,滤渣溴化钠回收。滤液蒸出大部分乙醇后,加蒸馏水析出白色结晶。过滤,水洗至中性,干燥,得邻乙氧基苯甲酰胺。收率约75%。也可采用氯乙烷代替溴乙烷进行乙基化反应,但需要较高压力。
  • 2-乙氧基苯甲酰胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 E0222 2-乙氧基苯甲酰胺 2-Ethoxybenzamide 500G 1330元 2014/06/02 E0222 2-乙氧基苯甲酰胺 2-Ethoxybenzamide 25G 228元 2010/06/21 117870050 2-乙氧基苯甲酰胺 2-Ethoxybenzamide 97% 5 GR 233元
  • 用途二:该品是解热镇痛药,其镇痛效力为水杨酸胺的2.3倍,为阿司匹林的7.5倍。用于治疗头痛、神经痛、腰痛、风湿性关节痛及伤风感冒等。鼠口服LD50为1160mg/kg。
  • 图谱信息:2-乙氧基苯甲酰胺(938-73-8)Raman光谱 2-乙氧基苯甲酰胺(938-73-8)核磁图( 1 HNMR) 2-乙氧基苯甲酰胺(938-73-8)核磁图( 13 CNMR) 2-乙氧基苯甲酰胺(938-73-8)质谱(MS) 2-乙氧基苯甲酰胺(938-73-8)红外图谱(IR1) 2-乙氧基苯甲酰胺(938-73-8)红外图谱(IR2)
  • 用途一:用作解热镇痛药,用于治疗发热、头痛、神经痛、关节痛、类风湿性关节炎、牙痛、痛经等病症
  • TCI Shanghai:2-乙氧基苯甲酰胺 2-Ethoxybenzamide,>;98.0%(GC)(938-73-8)
  • Acros Organics:2-乙氧基苯甲酰胺 2-Ethoxybenzamide, 97%(938-73-8)
  • Sigma Aldrich:938-73-8(sigmaaldrich)
  • MOL 文件:938-73-8.mol
  • 海关编码:29242995
  • Alfa Aesar:2-乙氧基苯甲酰胺,97% 2-Ethoxybenzamide, 97%(938-73-8)

系列性分类


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