3,5-Dinitrobenzamide 3,5-二硝基苯甲酰胺

CAS 121-81-3 MFCD00007985

化学结构图

121-81-3
SMILES: NC(=O)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1

化学属性

Mol. FormulaC7H5N3O5
Mol. Weight211
Melting Point183-185
TSCANo
Flash Point2 °C
Appearance 2-甲基-3,5-二硝基苯甲酰胺(148-01-6)为淡黄色或淡黄褐色粉末;无臭,味苦。2-甲基-3,5-二硝基苯甲酰胺(148-01-6)在丙酮中溶解,在乙醇中微溶,在氯仿或乙醚中极微溶解,在水中不溶。

别名和识别编码

Chemical Name3,5-Dinitrobenzamide
MDL NumberMFCD00007985
CAS Number121-81-3
Synonym 3,5-DINITRO-O-TOLUAMIDE 二甲硫胺硝酸盐(DIMETHIALIUM MONONITRATE) 3,5-dinitro-o-toluamid NITROMIDE 3,5-dinitro-toluamide(DOT) BPV93 DINITOLMIDE 二硝甲苯酰胺 Robenidine HCl, Vetranal Nitromide 2-甲基-3,5二硝基苯甲酰胺 d.o.t. 2-methyl-3,5-dinitro-benzamid AMIDE 3,5-DINITRO-O-TOLUIC ACID
PubChem Substance ID4511
Beilstein Registry Number7096825
EC Number204-499-8
Merck Number14,6612
Chemical Name Translation3,5-二硝基苯甲酰胺
LabNetwork Molecule IDLN01343419
InChIInChI=1S/C7H5N3O5/c8-7(11)4-1-5(9(12)13)3-6(2-4)10(14)15/h1-3H,(H2,8,11)
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分类

  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Antibiotics, Chemical Structure, Chromatography, Clinical Standards, N, NA - NI, Others
  • {SNA} Amides, Building Blocks, C2 to C7, Carbonyl Compounds, Chemical Synthesis, Organic Building Blocks

安全信息

WGK Germany3
GHS Symbol
Hazard statements
  • H302 Harmful if swallowed 吞食有害
RTECSCV4752300
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Signal word
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
Risk Statements
  • R36 Irritating to eyes 刺激眼睛
  • R22 Harmful if swallowed 吞咽有害
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R11 Highly flammable 非常易燃
Hazard Codes Xn Xn,F
Storage condition 0-6°C
UN Number UN 1648 3/PG 2
Precautionary statements 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : 900 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   7,488,1965

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 320 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   7,488,1965

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - turkey
DOSE/DURATION           : 1150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   7,488,1965

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   7,488,1965

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION

其他信息

  • MOL 文件:148-01-6.mol
  • 用途三:作为抗球虫药，本品对家畜、家禽球虫病的预防和治疗具有特效。本品用量效，无任何副作用，无毒性，性能稳定，添加于饲料中不分解。除能防治球虫病外，还能促进家禽的 体重增长（增重率13.8%），提高饲料利用率。本品溶于水后，对厌食的病鸡具有诱食的香味，用药效果极佳。用法和用量可以本品62g于1t饲料混匀后，用于鸡等家禽、家畜饲用，预防量减半；以本品4g溶于10kg水中，用于鸡等家禽、家畜饮用，预防量减半；可用于鸡饲料，最大用量为62.0g/t，产蛋期禁用，停药期3天。
  • 用途二:作为抗球虫药，对小肠球虫中的毒海艾美尔氏（艾氏）球虫的防治效果最好，对柔嫩艾氏球虫、波氏艾氏球虫和巨型艾氏球虫也有效。可用于鸡饲料，最大用量为125g/t，产蛋期禁用。
  • MSDS 信息:3,5-Dinitro-o-toluamide(148-01-6).msds
  • 用途一:用于饲料中能促进鸡的生长
  • Sigma Aldrich:148-01-6(sigmaaldrich)
  • 上游原料:硫酸 --> 氧氯化硫 --> 硝酸 --> 氢氧化铵 --> 3,5-二硝基-2-甲基苯甲酸
  • 方法一:以邻甲基酸为原料，经硝化得3，5-二硝基邻甲基苯甲酸，再用二氯亚砜酰氯化、氨水氨化得产品。
  • 方法二:合成路线与维生素B1生产类似，可参见维生素B1（03002）。

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Amides - Carbonyl Compounds
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Clinical Standards - Chromatography
  5. Antibiotics - Clinical Standards
  6. Chemical Structure - Antibiotics
  7. Others - Chemical Structure

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