2,2’-((5-Carboxy-4-(Carboxymethyl)-3-Cyanothiophen-2-Yl)Azanediyl)Diacetic Acid, Distrontium Salt 2,2’-((5-羧基-4-((羧甲基)-3-氰基噻吩-2-基)氮杂二基)二乙酸二锶盐
CAS 135459-87-9 MFCD09038742
化学结构图
SMILES: N#CC1=C(SC2=C1CC(=O)O[Sr]OC2=O)N1CC(=O)O[Sr]OC(=O)C1
化学属性
| Mol. Formula | C12H6N2O8SSr2 |
|---|---|
| Mol. Weight | 513 |
别名和识别编码
| Chemical Name | 2,2’-((5-Carboxy-4-(Carboxymethyl)-3-Cyanothiophen-2-Yl)Azanediyl)Diacetic Acid, Distrontium Salt |
|---|---|
| CAS Number | 135459-87-9 |
| Alfabeta Name | STRONTIUMCARBOXYLATOCARBOXYLATOMETHYLCYANOTHIOPHENYLAZANEDIYLDIACETATE 225432((()))--------,' |
| MDL Number | MFCD09038742 |
| Synonym | Ranelic Acid Strontium Salt |
| Chemical Name Translation | 2,2’-((5-羧基-4-((羧甲基)-3-氰基噻吩-2-基)氮杂二基)二乙酸二锶盐 |
| Beilstein Registry Number | 10746913 |
| Reaxys-RN | 10746913 |
| Merck Number | 8106 |
| PubChem Substance ID | 253660598 |
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资金保障
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分类
- Inhibitors
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
- Bone metabolism modulator; inhibits bone resorption while maintaining bone formation. Antiosteoporotic.
相关文献及参考
- [2]. Marie PJ. Strontium ranelate: a dual mode of action rebalancing bone turnover in favour of bone formation. Curr Opin Rheumatol. 2006 Jun;18 Suppl 1:S11-5.
- Buehler, J., et al.: Bone, 29, 176 (2001),
- Henrotin, Y., et al.: J. Bone Miner. Res.,16, 299 (2001),
- Meunier, P.J., et al.: N. Engl. J. Med., 350, 459 (2004),
- [1]. Bonnelye E, Chabadel A, Saltel F, Jurdic P. Dual effect of strontium ranelate: stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro. Bone. 2008 Jan;42(1):129-38. Epub 2007 Sep 12.
- [1]. Bonnelye E, Chabadel A, Saltel F, Jurdic P. Dual effect of strontium ranelate: stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro. Bone. 2008 Jan;42(1):129-38. Epub 2007 Sep 12.
- [2]. Marie PJ. Strontium ranelate: a dual mode of action rebalancing bone turnover in favour of bone formation. Curr Opin Rheumatol. 2006 Jun;18 Suppl 1:
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P273 Avoid release to the environment. 避免释放到环境中。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P302
- P302+P352+P312+P362+P364
- P304+P340+P312
- P305+P351+P338+P337+P313
- P330 Rinse mouth. 漱口
- P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H302+H312+H332
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