D-Threonine D-苏氨酸

CAS 632-20-2 MFCD00064269

化学结构图

632-20-2
SMILES: C[C@H](O)[C@@H](N)C(=O)O

化学属性

Mol. FormulaC4H9NO3
Mol. Weight119.12
Melting Point274°C
TSCANo
Density1.307
Solubility可溶
Appearance (大鼠,腹腔)5361 mg/kg。 +12°-+16°(0.5-2.0 mg/ml,5 mol/L HCl);LD 25 无色结晶状物质;无臭,味甜;溶于水,不溶于乙醇,乙醚和氯仿;分解点为251-253℃;比旋光度[α] D 50 +22°-+26°(0.5-2.0 mg/ml,H2O),[α]
Refractive index28 ° (C=3, H2O)
Boiling Point345.8°C at 760 mmHg

别名和识别编码

Chemical NameD-Threonine
Synonym D-Threonine {LY} D-Threonine {} {LY} D-Threonine {} {} {LY} D-Threonine {} {} {} {LY} D-Threonine {} {} {} {} {LY} D-Threonine {} {} {} {} {} {LY} D-Threonine {} {} {} {} {} {} {LY} D-Threonine {} {} {} {} {} {} {} {LY} D-Threonine {} {} {} {} {} {} {} {} {LY} D-Threonine {} {} {} {} {} {} {} {} {} {LY} D-Threonine {} {} {} {} {} {} {} {} {} {} {LY} D-Threonine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-Threonine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-Threonine {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-Threonine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-Threonine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-Threonine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-Threonine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
MDL NumberMFCD00064269
PubChem Substance ID69435
Beilstein Registry Number4(3)1625
CAS Number632-20-2
EC Number211-171-8
Reaxys-RN1721643
Merck Number9380
Chemical Name TranslationD-苏氨酸
Wiswesser Line NotationQY1&YZVQ -D
InChIKeyAYFVYJQAPQTCCC-STHAYSLISA-N
LabNetwork Molecule IDLN00153227
InChIInChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m0/s1
Canonical SMILESOC([C@@H]([C@@H](O)C)N)=O
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分类

  • {SA} Amino Acid Derivatives, Amino Acids, Biochemicals and Reagents, Chemical Biology, Chemical Synthesis, Peptide Chemistry, Threonine
  • {SNA} Amino Acid Derivatives, Chemical Biology, Chemical Synthesis, Peptide Chemistry, Threonine
  • {SNA} Amino Acids, Amino Acids & Derivatives, Chemical Biology, Chemical Synthesis, Peptide Chemistry, Threonine, 生化试剂
  • {Chemicalbook} 生物化学品: 生化试剂: 氨基酸及其衍生物
  • {SNA} Amino Acid Derivatives, Amino Acids, Chemical Biology, Chemical Synthesis, Peptide Chemistry, Threonine, 生化试剂

相关文献及参考

  • Beilstein:4(3)1625
  • For conversion to enantiomerically pure 1,3-butanediol, see: Synth. Commun ., 21, 2295 (1991).
  • [1]. D-Threonine

安全信息

WGK Germany1
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECSXO8580000
Signal word Warning
GHS Symbol
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Storage condition 2-8°C, protect from light, stored under nitrogen {LY} 2-8°C, protect from light, stored under nitrogen Store at RT. {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5361 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - dyspnea
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   ABBIA4 Archives of Biochemistry and Biophysics.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.31-    1951-  Volume(issue)/page/year:
   64,319,1956

Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激

其他信息

  • 上游原料:氯乙酰氯 --> DL-苏氨酸 --> 酰化氨基酸水解酶
  • 溶于水。
  • 下游产品:L-2-氨基-3-甲基戊酸 --> 头孢拉宗
  • 方法一:以DL-苏氨酸为原料,在碱性条件下与氯乙酰氯反应,减压浓缩后用丙酮萃取,最后由酰化酶I拆分得产品。
  • 图谱信息:D-苏氨酸(632-20-2)红外图谱(IR2) D-苏氨酸(632-20-2)核磁图( 13 CNMR) D-苏氨酸(632-20-2)质谱(MS) D-苏氨酸(632-20-2)红外图谱(IR1)
  • 用途一:用于生化研究。
  • Acros Organics:D-苏氨酸 D-Threonine, 98%(632-20-2)
  • Alfa Aesar:D-苏氨酸,99% D-Threonine, 99%(632-20-2)
  • Sigma Aldrich:632-20-2(sigmaaldrich)
  • 参考质量标准:纸层析合格,比旋光度[α] 25 D +27°-+28°(0.5-2.0 mg/ml,H2O)。
  • TCI Shanghai:D-(+)-苏氨酸 D-(+)-Threonine,>;98.0%(T)(632-20-2)
  • 比旋光度:28 ° (c=6, water)
  • D-苏氨酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 62021531 D-苏氨酸;D-α-氨基-β-羟基丁酸;D-羟基丁氨酸;D-异赤丝藻氨基酸 1g 20元 2011/04/16 T0228 D-(+)-苏氨酸 D-(+)-Threonine 25G 960元 2011/04/16 T0228 D-(+)-苏氨酸 D-(+)-Threonine 500G 8010元
  • MOL 文件:632-20-2.mol

系列性分类


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