2-(Trimethylsilyl)ethanol 2-(三甲硅基)乙醇

CAS 2916-68-9 MFCD00002825

化学结构图

2916-68-9
SMILES: C[Si](C)(C)CCO

化学属性

Mol. FormulaC5H14OSi
Mol. Weight118.25
Boiling Point145°C at 760 mmHg
Density0.825
Refractive index1.4230 to 1.4250
Flash Point56°C
TSCANo
Solubility可溶

别名和识别编码

Chemical Name2-(Trimethylsilyl)ethanol
CAS Number2916-68-9
Alfabeta NameTRIMETHYLSILYLETHANOL 2-
MDL NumberMFCD00002825
Synonym (2-Hydroxyethyl)-trimethylsilan (2-Hydroxyethyl)trimethylsilane {Chemicalbook} (2-hydroxyethyl)trimethyl-silan (2-羟基乙基)三甲基硅烷 2-(TRIMETHYLSILYL)ETHANAL 2-(TRIMETHYLSILYL)ETHANOL 2-(Trimethylsilyl)ethyl alcohol 2-(trimethylsilyl)-ethanol 2-(trimethylsilyl)ethanol 2-(三甲基硅基)乙醇 2-(三甲基硅基)乙醇, 98+% 2-(三甲硅基)乙醇 2-HYDROXYETHYLTRIMETHYLSILANE 2-Hydroxyethyltrimethylsilane 2-TMSE 2-hydroxyethyltrimethylsilane 2-trimethylsilanyl-ethanol Ethanol, 2-(trimethylsilyl)- TIMTEC-BB SBB009030 TMS ethanol trimethylsilylethanol
EC Number220-844-5
Beilstein Registry Number1732034
PubChem Substance ID87577204
Reaxys-RN1732034
Chemical Name Translation2-(三甲硅基)乙醇
InChIKeyZNGINKJHQQQORD-UHFFFAOYSA-N
Wiswesser Line NotationQ2-SI-1&1&1
LabNetwork Molecule IDLN00009690
InChIInChI=1S/C5H14OSi/c1-7(2,3)5-4-6/h6H,4-5H2,1-3H3
Canonical SMILESC[Si](CCO)(C)C
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分类

  • {SNA} Chemical Synthesis, Protecting and Derivatizing Reagents, Protection and Derivatization, Silicon-Based, Synthetic Reagents
  • {uni_hamburg} no charge; alcohol; 1fragment

产品应用

  • 经由相关异氰酸酯的醇解,合成Teoc-protected 胺。也是羧基和磷酸根基团的保护试剂。

相关文献及参考

  • Beilstein:4(4)3951
  • Short: III/35F
  • Carboxyl groups can be protected as 2-(trimethylsilyl)ethyl (TMSE) esters by carbodiimide coupling: Helv. Chim. Acta, 60, 2711 (1977); J. Org. Chem., 62, 93 (1997), from the acid chloride in pyridine: Helv. Chim. Acta, 60, 3039 (1977), or refluxing the acid in THF in the presence of TMS chloride: J. Am. Chem. Soc., 106, 3030 (1984). The TMSE protecting group is useful in peptide synthesis. Cleavage is readily effected with TBAF in DMF or DMSO: Helv. Chim. Acta, 60, 2711 (1977); Bioorg. Med. Chem. Lett., 3, 437 (1993).
  • Short: EINECS

安全信息

Warnings FLAMMABLE
Signal word Warning
GHS Symbol
WGK Germany3
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护;
Risk Statements
  • R10 Flammable 易燃
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
  • P241+P242+P243
  • P242 Use only non-sparking tools. 只能使用无火花工具。
  • P243 Take precautionary measures against static discharge. 采取预防措施,防止静电放电。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P302+P352+P332+P313+P362+P364
  • P303+P361+P353
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P370+P378
  • P403+P235
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
RTECSKM5480000
Packing GroupIII
UN Number 1987 1993
Hazard statements
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Hazard Codes 3
Storage condition 0-10 0-10°C 0-6°C 2-8°C
Hazard Class3
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1122 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DANKAS Doklady Akademii Nauk SSSR.  Proceedings of the Academy of Sciences
   of the USSR.  For English translation, see DBIOAM and DKBSAS.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-    1933-
   Volume(issue)/page/year: 229,1011,1976

其他信息

  • MOL 文件:2916-68-9.mol
  • 溶于水。
  • Hazard Note:Flammable
  • 2-(三甲硅基)乙醇价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 T1441 2-(三甲硅基)乙醇 2-(Trimethylsilyl)ethanol 5ML 559元 2014/06/02 T1441 2-(三甲硅基)乙醇 2-(Trimethylsilyl)ethanol 25ML 1710元 2010/06/21 210480500 2-(三甲硅基)乙醇 2-(Trimethylsilyl)ethanol 99% 50 ML 5354元
  • Alfa Aesar:2-(三甲基硅基)乙醇,98+% 2-(Trimethylsilyl)ethanol, 98+%(2916-68-9)
  • 图谱信息:2-(三甲硅基)乙醇(2916-68-9)质谱(MS) 2-(三甲硅基)乙醇(2916-68-9)核磁图( 1 HNMR) 2-(三甲硅基)乙醇(2916-68-9)红外图谱(IR1) 2-(三甲硅基)乙醇(2916-68-9)核磁图( 13 CNMR)
  • MSDS 信息:2-(Trimethylsilyl)ethanol(2916-68-9).msds
  • TCI Shanghai:2-三甲基硅基乙醇 2-(Trimethylsilyl)ethanol,>;95.0%(GC)(2916-68-9)
  • TSCA:No
  • Acros Organics:2-(三甲硅基)乙醇 2-(Trimethylsilyl)ethanol, 99%(2916-68-9)
  • 用途一:经由相关异氰酸酯的醇解,合成Teoc-protected 胺。也是羧基和磷酸根基团的保护试剂。
  • 2-(三甲硅基)乙醇价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 T1441 2-(三甲硅基)乙醇 2-(Trimethylsilyl)ethanol 5ML 862元 2011/04/16 T1441 2-(三甲硅基)乙醇 2-(Trimethylsilyl)ethanol 25ML 2630元 2010/06/21 210480500 2-(三甲硅基)乙醇 2-(Trimethylsilyl)ethanol 99% 50 ML 5354元
  • Sigma Aldrich:2916-68-9(sigmaaldrich)
  • 海关编码:29310095

系列性分类


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