• 原料直供
• 试剂商城
• 直接询价

分类

• {SNA} Amine Protection, Chemical Biology, Chemical Synthesis, Other Protecting and Derivatizing Reagents,
• {SNA} Amine Protection, Chemical Biology, Chemical Synthesis, Others, Peptide Chemistry, Protecting and Derivatizing Reagents, Protection and Derivatization, Synthetic Reagents
• {SNA} Chemical Reagents, Amine Protection, Chemical Biology,
• {SNA} Amine Protection,
• {SNA} Amine Protection, Chemical Biology, Chemical Reagents, Chemical Synthesis, Development Quantities for Research, Other Protecting and Derivatizing Reagents, Peptide Chemistry, Protecting and Derivatizing Reagents, Protection and Derivatization, Synthetic Reagents

产品应用

• 氨基酸BOC试剂。有机合成中用来引入叔丁氧羰（BOC）保护基团，特别适用于氨基酸的氨基保护。
• 三叔丁氧羰基保护的肼可以在发色试剂中制备芴甲氧羰基?酯以监测固相醛类。
• 用于制备叔丁氧羰基保护的胺类的试剂。
• 用于引入叔丁氧羰基保护基团的试剂。
• 通过 Lewis 酸催化作用可以保护叔丁氧羰基衍生物等醇类。
• 通过叔丁氧羰基氨基丙炔与甲醛、二异丙胺以及溴化铜的?反应来制备氨甲基丙二烯，是许多牛血浆胺氧化酶灭活剂?的组分。

相关文献及参考

• For a brief feature on uses of the reagent in synthesis, see: Synlett, 1995 (2001).
• The Boc group is readily cleaved with acid, most often Trifluoroacetic acid, L06374.
• For Boc protection of phenols, alcohols, thiols etc. under phase-transfer conditions, see: Can. J. Chem., 63, 153 (1985).
• Carboxylic acids have also been converted to Boc-protected amines, via a one-pot Curtius rearrangement, using the reagent in the presence of sodium azide, with catalytic amounts of TBAB and zinc triflate: Org. Lett., 7, 4107 (2005).
• In the presence of 1 equivalent of DMAP in acetonitrile, arylamines are converted to isocyanates, generally in high yield; the dicarbonate here behaves as a convenient phosgene replacement: Angew. Chem. Int. Ed., 34, 2497 (1995). The same reagent system has also been applied to nitroalkanes for the ambient temperature generation of nitrile oxides which were trapped in situ with dipolarophiles: Synthesis, 309 (1997). Carboxyli
• Rapid and efficient formation of Boc derivatives of amines, catayzed by Copper(II)­ tetrafluoroborate hexahydrate, 26127 has been described: Tetrahdron Lett., 47, 1087 (2006).
• Amides can be protected in the presence of a catalytic quantity of DMAP (4-(Dimethyl­amino)­pyridine, A13016): J. Org. Chem., 48, 2424 (1983); Acta Chem. Scand. B, 40, 745 (1986); the amide link of the product undergoes facile alkaline hydrolysis or methanolysis.
• In the presence of 1 equivalent of DMAP in acetonitrile, arylamines are converted to isocyanates, generally in high yield; the dicarbonate here behaves as a convenient phosgene replacement: Angew. Chem. Int. Ed., 34, 2497 (1995). The same reagent system has also been applied to nitroalkanes for the ambient temperature generation of nitrile oxides which were trapped in situ with dipolarophiles: Synthesis, 309 (1997). Carboxylic acids can be esterified in the presence of a catalytic amount of DMAP: Synlett, 263 (2004).

安全信息

GHS Symbol

其他信息

• 遇水分解成叔丁醇和CO2，因此瓶装试剂，在吸潮后会导致瓶内压力升高，包装开启时注意个人防护。