6-Hydroxydopamine hydrobromide 6-羟基多巴胺

CAS 636-00-0 MFCD00012894

化学结构图

636-00-0
SMILES: Br.NCCc1cc(O)c(O)cc1O

化学属性

Mol. Formula(HO)3C6H2CH2CH2NH2· HBr
Mol. Weight250.09
Melting Point216-220 °C(lit.)
Appearance solid

别名和识别编码

Chemical NameOxidopamine hydrobromide
MDL NumberMFCD00012894
CAS Number636-00-0
Synonym 2,4,5-TRIHYDROXYPHENETHYLAMINE HYDROBROMIDE 2,4,5-Trihydroxyphenethylamine 2,4,5-Trihydroxyphenethylamine hydrobromide, 2,5-Dihydroxytyramine hydrobromide, 2-(2,4,5-Trihydroxyphenyl)ethylamine hydrobromide, 6-OHDA 2,4,5-Trihydroxyphenethylamine hydrobromide 2,5-Dihydroxytyramine hydrobromide 2-(2,4,5-Trihydroxyphenyl)ethylamine hydrobromide 6-OHDA 2,4,5-三羟基苯乙胺氢溴酸盐 2,4-benzenetriol,5-(2-aminoethyl)-hydrobromide 2,5-DIHYDROXYTYRAMINE HYDROBROMIDE 2,5-二羟基酪胺氢溴酸盐 2-(2,4,5-TRIHYDROXYPHENYL)ETHYLAMINE HYDROBROMIDE 5-(2-aminoethyl)-4-hydroxypyrocatechol hydrobromide 6-HYDROXYDOPAMINE HBR 6-HYDROXYDOPAMINE HYDROBROMIDE 6-HYDROXYDOPAMINE HYDROBROMIDE 99% 6-HYDROXYDOPAMINE HYDROBROMIDE WITH ASCO RBIC ACID 6-Hydroxydopamine hydrbromide 6-Hydroxydopamine hydrobromide 6-Hydroxydopamine hydrogen bromide 6-Hydroxydopaminehydrobromide/ascorbicacid 6-Hydroxydopamine·hydrogen bromide 6-羟基多巴胺氢溴酸盐 6-羟多巴胺 KEMPTIDE, SYNTHETIC, >97% PURITY 氢溴酸-6-羟基多巴胺
PubChem Substance ID176170
Beilstein Registry Number3713280
EC Number211-247-0
Chemical Name Translation6-羟基多巴胺
LabNetwork Molecule IDLN00195678
InChIInChI=1S/C8H11NO3.BrH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H
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分类

  • {SNA} Amino Alcohols, Bioactive Small Molecules, Building Blocks, Cell Biology, Chemical Synthesis, H, Organic Building Blocks, Oxygen Compounds
  • {SNA} Adrenergics, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, H, Neuroscience, Neurotransmission, Neurotransmitters, Others
  • {SA} Amino Alcohols, Bioactive Small Molecules, Building Blocks, Cell Biology, Chemical Synthesis, H, Organic Building Blocks, Oxygen Compounds
  • {SNA} Amino Alcohols, Bioactive Small Molecule Alphabetical Ind

相关文献及参考

  • [2]. Soto-Otero R et al. Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson's disease. J Neurochem. 2000 Apr;74(4):1605-12.
  • [1]. Fujita H et al. Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway. Brain Res. 2006 Oct 3;1113(1):10-23.
  • [1]. Fujita H et al. Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway. Brain Res. 2006 Oct 3;1113(1):10-23.
  • [2]. Soto-Otero R et al. Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson's disease. J Neurochem. 2000 Apr;74(4):1605-12.

安全信息

WGK Germany3
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
RTECSDC4600000
GHS Symbol
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Hazard Codes Xi
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition 2-8°C 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 100 mg/kg
SEX/DURATION            : female 21-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Paternal Effects - other effects on male
   Reproductive - Maternal Effects - parturition
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 76,415,1986

其他信息

  • MOL 文件:636-00-0.mol
  • 用途一:生化试剂，可诱发帕金森病大鼠模型。
  • F:3-10
  • color:tan to brown
  • Sigma Aldrich:636-00-0(sigmaaldrich)
  • 图谱信息:6-羟基多巴胺氢溴酸盐(636-00-0)红外图谱(IR1) 6-羟基多巴胺氢溴酸盐(636-00-0)红外图谱(IR2) 6-羟基多巴胺氢溴酸盐(636-00-0)质谱(MS)

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. H - Bioactive Small Molecules
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Amino Alcohols - Oxygen Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Amino Alcohols - Oxygen Compounds
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Neuroscience - Cell Signaling and Neuroscience
  5. Neurotransmission - Neuroscience
  6. Neurotransmitters - Neurotransmission
  7. Adrenergics - Neurotransmitters
  8. Others - Adrenergics
  1. Functional Group 官能团索引
  2. 1,2-diphenol
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Dopamine Receptor  (多巴胺受体)

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