p-Toluenesulfonic acid monohydrate 对甲苯磺酸一水合物

CAS 6192-52-5 MFCD00142137

化学结构图

6192-52-5
SMILES: Cc1ccc(S(=O)(=O)O)cc1.O

化学属性

Mol. FormulaC7H10O4S
Mol. Weight190.22
Density1.24
Vapor Density5.9 (vs air)
Melting Point96-99°C
Flash Point150°(302°F)
TSCAYes
Boiling Point428.9°C at 760 mmHg
Refractive index1.3825-1.3845
SolubilitySoluble in water, alcohols, and other polar organic solvents.
Stability易吸潮
pH:A

别名和识别编码

Chemical Namep-Toluenesulfonic acid monohydrate
Beilstein Registry Number3568023
PubChem Substance ID57648235
MDL NumberMFCD00142137
EC Number203-180-0
CAS Number6192-52-5
Synonym p-Toluenesulfonic acid (monohydrate) {LY} p-Toluenesulfonic acid (monohydrate) {} {LY} p-Toluenesulfonic acid (monohydrate) {} {} {LY} p-Toluenesulfonic acid (monohydrate) {} {} {} {LY} p-Toluenesulfonic acid (monohydrate) {} {} {} {} {LY} p-Toluenesulfonic acid (monohydrate) {} {} {} {} {} {LY} p-Toluenesulfonic acid (monohydrate) {} {} {} {} {} {} {LY} p-Toluenesulfonic acid (monohydrate) {} {} {} {} {} {} {} {LY} p-Toluenesulfonic acid (monohydrate) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} p-Toluenesulfonic acid (monohydrate) {} {} {} {} {} {} {} {} {} {LY} p-Toluenesulfonic acid (monohydrate) {} {} {} {} {} {} {} {} {} {} {LY} p-Toluenesulfonic acid (monohydrate) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} p-Toluenesulfonic acid (monohydrate) {} {} {} {} {} {} {} {} {} {} {} {} {LY} p-Toluenesulfonic acid (monohydrate) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} p-Toluenesulfonic a
Merck Number9533
Chemical Name Translation对甲苯磺酸一水合物
Reaxys-RN3568023
LabNetwork Molecule IDLN00193789
Canonical SMILESCC1=CC=C(S(O)(=O)=O)C=C1.O
信息真实价格透明    资金保障    专业采购外包团队在线服务   
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分类

  • {SNA} Acids, Acids & Bases, Chemical Synthesis, Derivatization Reagents, Derivatization Reagents TLC, Organic Acids, Synthetic Reagents, TLC Reagents, S-Z, TLC Visualization (Staining) Reagents (alphabetic sort), 分析/色谱, 分析试剂
  • {SNA} Chemical Synthesis, Organic Acids, Synthetic Reagents
  • {SNA} Acids, Acids & Bases, Chemical Synthesis, Derivatization Reagents, Derivatization Reagents TLC, Organic Acids, Synthetic Reagents, TLC Reagents, S-Z, TLC Visualization Reagents (alphabetic sort), 分析/色谱, 分析试剂
  • {SNA} Acids, Ac

产品应用

  • 有机合成、测定伯胺类、染料工业。

相关文献及参考

  • Adsorbed on silica gel, has been used for the dehydration of sec- and tert-alcohols to alkenes in good yield: Synthesis, 1159 (1985).
  • Esterifications: Org. Synth. Coll., 3, 146, 203, 610 (1955); 9, 722 (1998). Enamine formation: Org. Synth. Coll., 5, 277, 808 (1973); 6, 520 (1988). Protection of alcohols as their THP ethers: Org. Synth. Coll., 7, 334 (1990). Formation acetals: Org. Synth. Coll., 6, 567 (1988); 8, 155 (1993); 9, 251, 717 (1998), and oxazolidines: Org. Synth. Coll., 9, 300 (1998).
  • For examples of the numerous applications as an organic-soluble acid catalyst, see:
  • Merck: 14,9533
  • Merck: 14,9533 Beilstein:11,97
  • See also Pyridinium p-toluenesulfonate, A15708.

安全信息

Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H290 May be corrosive to metals 可能腐蚀金属。
  • H303 May be harmfully swallowed 吞食可能有害
WGK Germany1
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P330+P331+P310
  • P303+P361+P353
  • P303+P361+P353+P310+P363
  • P304+P340+P310
  • P305+P351+P338
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard Codes 8 C Xi
GHS Symbol
Signal word Danger
Safety Statements
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S37 Wear suitable gloves 戴适当手套；
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Risk Statements
  • R34 Causes burns 会导致灼伤
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges dust mask type N95 (US), Eyeshields, Faceshields, Gloves
RTECSDB7164000
Packing GroupIII
UN Number 2585 UN 2585 8/PG 3
Storage condition 2-8°C, sealed storage, away from moisture {LY} 2-8°C, sealed storage, away from moisture Hygroscopic Store at RT. {} {LY} 2-8°C, sealed storage, away from moisture {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage,
Hazard Class8

其他信息

  • F:3
  • Acros Organics:对甲苯磺酸单水合物 p-Toluenesulfonic acid monohydrate, pure, 97.5%(6192-52-5)
  • 对甲苯磺酸水合物价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30180116 甲苯-4-磺酸 100g 13.5元 2011/08/23 30180126 甲苯-4-磺酸 100g 11.2元 2011/08/23 30180128 甲苯-4-磺酸 500g 54.5元
  • TCI Shanghai:对甲苯磺酸一水合物 p-Toluenesulfonic Acid Monohydrate,>;98.0%(LC)(T)(6192-52-5)
  • 外观性质:白色单斜片状或柱状结晶体。
  • MOL 文件:6192-52-5.mol
  • MSDS 信息:对甲苯磺酸(6192-52-5).msds
  • 海关编码:29041000
  • 敏感性:Hygroscopic
  • 检测方法:T,MP
  • Sigma Aldrich:6192-52-5(sigmaaldrich)
  • 用途一:重要的有机合成中间体，适用于炸药、医药、合成树脂、聚醚、化妆品、烟草、食品等；在脂化、脱水、烷基化、脱烷基、贝克曼重排、聚合与解聚反应等反应单元用作催化剂、稳定剂；在医药上用于合成强力霉素，潘生丁、萘普生及用于生产阿莫西林、头孢羟氨苄中间体。环氧和氨基树脂、涂料等方面也有应用。
  • 蒸气密度:5.9 (vs air)
  • 用途二:有机合成、测定伯胺类、染料工业。
  • Alfa Aesar:对甲苯磺酸一水合物,ACS,98.5+% p-Toluenesulfonic acid monohydrate, ACS, 98.5+%(6192-52-5)
  • 下游产品:(R)-2-羟基-4-苯基丁酸乙酯 --> 吡咯咪唑 --> 4-(1,2,3-噻二唑-4-基)苄胺盐酸盐 --> 4-（4-氯苯基）-1，2，3-硫二唑-5-胺 --> 3-甲氧基羰基-3-亚砜 --> 2-（5-甲基-2-苯基1，3-氧杂醇-4-烷基）乙酸 --> (6R,7R)-3-[[(1-甲基-1H-四唑-5-基)硫]甲基]-7-[(R)-2-(4-乙基-2,3-二氧代-1-哌嗪甲酰氨基)-2-对羟基苯基-乙酰氨基]-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-甲酸 --> 4-(4-甲氧基苯基)-1,2,3-噻重氮-5-胺 --> 4-4-(三氟甲基)苯基-1,2,3-噻二唑-5-胺 --> N,N-二甲基丙烯基脲 --> : 仑氨西林 仑氨西林 --> 4-(4-溴苯基)-1,2,3-噻重氮 --> 2-氨基-4-甲基嘧啶-5-甲酸 --> 沙奎那韦 --> 4-吡啶乙硫醇盐酸盐 --> 羟乙酸甲酯 --> 4-溴-3-羰基戊酸甲酯 --> 去氧氟尿苷 --> 2-苯基咪唑啉 --> 4-甲基苯磺酸吡啶
  • 易溶于水、醇和醚，极易潮解，易使棉织物、木材、纸张等碳水化合物脱水而碳化，难溶于苯和甲苯。碱熔时生成对甲酚。本品有时会以含1分子结晶水或4分子结晶水存在。

系列性分类

  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Organic Acids - Synthetic Reagents
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Organic Acids - Synthetic Reagents
  1. Research Essentials 基础科研
  2. Essential Chemicals - Research Essentials
  3. Inorganic Salts, Solutions and Reagents - Essential Chemicals
  4. ACS Grade - Inorganic Salts, Solutions and Reagents
  1. Research Essentials 基础科研
  2. Essential Chemicals - Research Essentials
  3. Inorganic Salts, Solutions and Reagents - Essential Chemicals
  4. Reagent Grade - Inorganic Salts, Solutions and Reagents
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Lewis Acids 路易斯酸
  4. Titanium - Lewis Acids
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Reagents
  3. Derivatization Reagents 衍生分析试剂
  4. Derivatization Reagents TLC - Derivatization Reagents
  5. TLC Visualization Reagents (alphabetic sort) - Derivatization Reagents TLC
  6. TLC Reagents, S-Z - TLC Visualization Reagents (alphabetic sort)
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Reagents
  3. Derivatization Reagents 衍生分析试剂
  4. Derivatization Reagents TLC - Derivatization Reagents
  5. TLC Reagents - Derivatization Reagents TLC
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Reagents
  3. Derivatization Reagents 衍生分析试剂
  4. Derivatization Reagents TLC - Derivatization Reagents
  5. TLC Reagents - Derivatization Reagents TLC
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Sulfur Compounds 硫化合物
  5. Sulfonates/Sulfinates - Sulfur Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Sulfur Compounds 硫化合物
  5. Sulfonic/Sulfinic Acids 磺酸/亚磺酸
  1. Analytical & Chromatography 分析化学与色谱
  2. Derivatization Reagents
  3. TLC Visualization Reagents (alphabetic sort)
  4. TLC Reagents, N-R
  1. Analytical & Chromatography 分析化学与色谱
  2. Derivatization Reagents
  3. Derivatization Reagents TLC
  4. TLC Visualization Reagents (alphabetic sort)
  5. TLC Reagents, N-R

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