Trichloromethyl Chloroformate 氯甲酸三氯甲酯

CAS 503-38-8 MFCD00015553

化学结构图

503-38-8
SMILES: O=C(Cl)OC(Cl)(Cl)Cl

化学属性

Mol. FormulaC2Cl4O2
Mol. Weight198
Refractive indexn20/D 1.458
Boiling Point20 °C/10 mmHg(lit.)
Density1.639 g/mL at 20 °C
Flash Point>110°(230°F)
TSCAYes
Melting Point-57°
SolubilityMAY DECOMPOSE

别名和识别编码

Chemical NameTrichloromethyl Chloroformate
Synonym Carbonochloridicacid,trichloromethylester DIPHOSGENE Carbonochloridic acid, trichloromethyl ester DP Trichloromethyl chlorocarbonate Trichloromethyl chloroformate chloro-formicacitrichloromethylester Trichloromethylchloroformate=Diphosgene chlorocarbonic acid trichloromethyl ester 氯甲酸三氯甲酯 Chloroformic acid trichloromethyl ester Trichloromethylchloroformate,98% Disphosgene 雙光氣 CHLOROFORMIC ACID TRICHLOROMETHYL ESTER Formic acid, chloro-, trichloromethyl ester 氯代甲酸三氯甲酯 Difosgen Perchlorameisensäuremethylester trichlormethylesterkyselinychlormravenci trichloromethyl carbonochloridate 氯甲酸三氯甲基酯(双光气)/0401禁空运 phosgene dimer Perstoff Diphosgene Trichlormethyl-chlorformiat Chlorameisensäure-trichlormethylester 双光气 氯代甲酸三氯甲酯 Methanol, trichloro-, chloroformate TRICHLOROMETHYL CHLOROFORMATE 双光气 carbonochloridicacidtrichloromethylester trichloro-methanochloroformate Chlorameisensäuretrichlormethylester trochloromethylchloroformate perchloromethylformate Carbonochloridic acid trichloromethyl ester Trichlormethylester kyseliny chlormravenci Trichlormethylchlorformiat Diphosgen
CAS Number503-38-8
PubChem Substance ID10426
EC Number207-965-9
Beilstein Registry Number970225
MDL NumberMFCD00015553
Merck Number14,3334
Chemical Name Translation氯甲酸三氯甲酯
Wiswesser Line NotationGXGGOVG
LabNetwork Molecule IDLN00851989
InChIInChI=1S/C2Cl4O2/c3-1(7)8-2(4,5)6
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分类

  • {SA} Chemical Synthesis, Deprotecting Reagents, Others, Protection and Derivatization, Synthetic Reagents
  • {uni_hamburg} no charge; carbonyl chloride; 1fragment
  • {SNA} Chemical Synthesis, Deprotecting Reagents, Other Deprotecting Reagents, Protection and Derivatization, Synthetic Reagents

产品应用

  • 光气替代物；原位炭催化分解成光气以及和氨基酸反应，生成N-羧基酸酐。

相关文献及参考

  • Merck: 14,3334 Beilstein: 3,IV,33
  • Convenient replacement for phosgene in many reactions, for example:
  • Dehydration of N-monosubstituted formamides to isocyanides: Angew. Chem. Int. Ed., 16, 259 (1977).
  • Short: III/38B
  • See also Triphosgene, A14932, and Oxalyl­ chloride, A18012.
  • Conversion of amines to isocyanates: J. Org. Chem., 41, 2070 (1976); Org. Synth. Coll ., 6, 715 (1988). For aliphatic amines, best results were obtained in the presence of the hindered amine 1,8-Bis(dimethyl­amino)­naphthalene, L00313: J. Org. Chem., 61, 3883 (1996).
  • Formation of nitriles from oximes Synthesis, 1037 (1986); or carboxamides: Tetrahedron Lett., 27, 2203 (1986).
  • Merck: 14,3334

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H330 Fatal if inhaled 吸入致命
  • H300 Fatal if swallowed 吞食致命
  • H300+H330
  • H302 Harmful if swallowed 吞食有害
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Hazard Codes T+
RTECSLQ7350000
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P303+P361+P353
  • P304+P340+P310
  • P305+P351+P338
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312+P330
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P301+P310
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
Signal word Danger
UN Number UN3390 1076/3277 UN 3277 6.1/PG 2
Risk Statements
  • R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有剧毒
  • R34 Causes burns 会导致灼伤
  • R26 Very toxic by inhalation 吸入极毒
  • R26/28 Very toxic by inhalation and if swallowed 吸入及吞食都有剧毒
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S27/28
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
Storage condition Moisture Sensitive 储存温度 2-8°C 2-8°C
Packing GroupI
Hazard Class6.1
Warnings 危化品目录(2015) 
TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 900 mg/m3/15M
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - ciliary function changes
   Lungs, Thorax, or Respiration - acute pulmonary edema
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   FMORAO Folia Morphologica (Prague).  (Plenum Pub. Corp. 233 Spring St., New
   York, NY 10013) V.13-    1965-  Volume(issue)/page/year: 19,5,1971

Restrict 危险品

其他信息

  • 用途一:用作军用毒气及有机合成工业的原料
  • F:8-10-19
  • 储运特性:库房通风低温干燥; 与氧化剂、碱类、活性碳、食品添加剂分开存放
  • 外观性质:无色液体，有窒息性。
  • 毒性分级:中毒
  • 急性毒性:吸入- 小鼠 LC50: 3600 毫克/ 立方米/ 10分; 吸入-兔子 LCL0: 900 毫克/立方米/15分
  • Sigma Aldrich:503-38-8(sigmaaldrich)
  • Alfa Aesar:氯甲酸三氯甲酯,98% Trichloromethyl chloroformate, 98%(503-38-8)
  • 可燃性危险特性:遇热、或遇碱、或接触活性碳分解有毒光气; 遇水、水蒸气产生有毒气体; 受热产生有毒氯化物烟雾
  • MOL 文件:503-38-8.mol
  • 氯甲酸三氯甲酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 243310100 氯甲酸三氯甲酯 Diphosgene 99% 10 ML 1170元 2010/06/21 243311000 氯甲酸三氯甲酯 Diphosgene 99% 100 ML 8521元 2010/05/25 A17444 氯甲酸三氯甲酯, 98% Trichloromethyl chloroformate, 98% 250g 5894元
  • MSDS 信息:氯代甲酸三氯甲酯(503-38-8).msds
  • 用途二:用于医药、农药、染料。
  • 下游产品:氯甲酸苄酯 --> 苯磺隆 --> 4-叔丁氧羰基-2-甲基哌嗪 --> 杀扑磷 --> 3-二已胺荃-1-丙胺
  • 类别:有毒物品
  • 敏感性:Moisture Sensitive
  • 用途三:光气替代物；原位炭催化分解成光气以及和氨基酸反应，生成N-羧基酸酐。
  • 遇热或活性炭则分解，放出光气，亦能被热水或碱类分解。有刺激性，毒性较强，具有窒息性。溶于乙醇、乙醚和苯。
  • Acros Organics:氯甲酸三氯甲基酯 Diphosgene, 99%(503-38-8)

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Halogenated Hydrocarbons 卤代烃
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Esters - Carbonyl Compounds
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Protection and Derivatization - Synthetic Reagents
  4. Deprotecting Reagents - Protection and Derivatization
  5. Others - Deprotecting Reagents
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Protection and Derivatization - Synthetic Reagents
  4. Deprotecting Reagents - Protection and Derivatization
  5. Others - Deprotecting Reagents
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Protection and Derivatization - Synthetic Reagents
  4. Deprotecting Reagents
  5. Fluoride Sources

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