(4-Chloro-2-methylphenoxy)acetic Acid (4-氯-2-甲基苯氧基)乙酸

CAS 94-74-6 MFCD00004306

化学结构图

94-74-6
SMILES: Cc1cc(Cl)ccc1OCC(=O)O

化学属性

Mol. FormulaC9H9ClO3
Mol. Weight200.62
Melting Point114-118°C
Density1.313
Flash Point2 °C
Solubility难溶于水,易溶于多数有机溶剂。
Boiling Point288.02 °C at 760 mmHg

别名和识别编码

Chemical Name(4-Chloro-2-methylphenoxy)acetic Acid
CAS Number94-74-6
Synonym MCPA {LY} MCPA {} {LY} MCPA {} {} {LY} MCPA {} {} {} {LY} MCPA {} {} {} {} {LY} MCPA {} {} {} {} {} {LY} MCPA {} {} {} {} {} {} {LY} MCPA {} {} {} {} {} {} {} {LY} MCPA {} {} {} {} {} {} {} {} {LY} MCPA {} {} {} {} {} {} {} {} {} {LY} MCPA {} {} {} {} {} {} {} {} {} {} {LY} MCPA {} {} {} {} {} {} {} {} {} {} {} {LY} MCPA {} {} {} {} {} {} {} {} {} {} {} {} {LY} MCPA {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} MCPA {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} MCPA {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} MCPA {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} MCPA {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} MCPA {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} MCPA {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} MCPA {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Beilstein Registry Number2051752
PubChem Substance ID7204
EC Number202-360-6
MDL NumberMFCD00004306
Reaxys-RN2051752
Merck Number5764
Chemical Name Translation(4-氯-2-甲基苯氧基)乙酸
Wiswesser Line NotationQV1OR DG B1
InChIInChI=1S/C9H9ClO3/c1-6-4-7(10)2-3-8(6)13-5-9(11)12/h2-4H,5H2,1H3,(H,11,12)
Canonical SMILESO=C(O)COC1=CC=C(Cl)C=C1C
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分类

  • {Chemicalbook} 农药: 除草剂: 苯氧羧酸类除草剂
  • {SNA} Building Blocks, C9, Carbonyl Compounds, Carboxylic Acids, Chemical Synthesis, Or
  • {SA} Alpha sort, Alphabetic, Analytical Standards, Analytical/Chromatography, Chromatography, Environmental Standards, H-M, Herbicides
  • {SNA} Alphabetical Index of Analytical Standards,
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Chromatography, Environmental Standards,
  • {SNA} Building Blocks, C9, Carbonyl Compounds, Carboxylic Acids, Chemical Synthesis, Organic Building Blocks
  • {SNA} All Herbicide Standards,

产品应用

  • 激素型除草剂

相关文献及参考

  • Elliott, B., et al.: Mutagenesis, 20, 3 (2005),
  • Merck 14 ,5764
  • Short: IV/8A Title: Enthalpies of Fusion and Transition of Organic Compounds Author: Zhang, Z.-Y.; Frenkel, M.; March, K.N.; Wilhoit, R.C. Editor: Marsh, K.N. Source: Landolt-Börnstein, New Series Volume: IV/8A Year: 1995 Keyword: organic compounds; enthaly of fusion; melting point; phase transition ISBN: 3-540-58854-X ISBN: 978-3-540-58854-2 Internet Resource: DOI:10.1007/b55145 RefComment: VIII, 588 pages.
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15

安全信息

Precautionary statements
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P332+P313
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P301+P312+P330
  • P302+P350
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338+P310
GHS Symbol
Signal word Danger
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
  • H318 Causes serious eye damage 严重伤害眼睛
  • H302 Harmful if swallowed 吞食有害
  • H302+H332
  • H332 Harmful if inhaled 吸入有害
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H312 Harmful in contact with skin 皮肤接触有害
Hazard Codes F,Xn Xn,F Xn Xn,N
WGK Germany3
RTECSAG1575000
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S37 Wear suitable gloves 戴适当手套;
  • S39 Wear eye/face protection 戴眼睛/面孔保护装置;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
Risk Statements
  • R11 Highly flammable 非常易燃
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
  • R38 Irritating to skin 刺激皮肤
  • R36 Irritating to eyes 刺激眼睛
  • R22 Harmful if swallowed 吞咽有害
  • R50/53
UN Number 2765 UN 2765
Storage condition 2-8°C, protect from light {LY} 2-8°C, protect from light APPROX 4°C {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Bird - quail
DOSE/DURATION           : 377 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FMCHA2 Farm Chemicals Handbook.  (Meister Pub., 37841 Euclid Ave.,
   Willoughy, OH 44094)  Volume(issue)/page/year: -,C191,1991

{

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   WRPCA2 World Review of Pest Control.  (London, UK)  V.1-10, 1962-71.
   Discontinued.  Volume(issue)/page/year: 9,119,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
   Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)  V.1-
   1990-  Volume(issue)/page/year: 1,86,1990

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1370 mg/m3/4H
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
   Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)  V.1-
   1990-  Volume(issue)/page/year: 1,86,1

TYPE OF TEST            : LD50 - Lethal dos

TYPE OF TEST            : DNA inhibition
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 55,197,1978

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 10 umol/L/1H
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 5,703,1984

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 250 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 204,615,1988

TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Mold - Aspergillus nidulans
DOSE/DURATION           : 1500 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 204,615,1988

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 30 umol/L/3H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 60,291,1979

TYPE OF TEST            : Sister chromatid exchange
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - hamster
DOSE/DURATION           : 900 mg/kg/9D (Intermittent)
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfie

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 3 gm/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 33,1479,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1 gm/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 33,1479,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 2 gm/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 33,1479,1983

其他信息

  • 用途三:该品商品为2-甲-4-氯钠盐,
  • 方法二:由邻甲酚经缩合、酸化、氯化而得。将26.24kg邻甲酚、13.9kg水、35%的氢氧化钠溶液27.37kg投入缩合锅内,在70℃以下搅拌配合成邻甲酚钠盐。在21.88kg氯乙酸和41.66kg水中,在25℃以下慢慢加入35%的氢氧化钠溶液26.56kg,使pH值为5-6,在60℃条件下酸化20min。将反应物在脱酚槽内加热至90-95℃,通过热蒸气脱酚。然后在pH值为1-2、60-65℃条件下氯化。再经冷却、过滤、水洗即得2-甲-4-氯。原药2-甲-4-氯钠原药为深褐色粉末,按HG 2-1460-82,有效成分含量≥56.0%。原料消耗定额:邻甲酚730kg/t、液氯600kg/t、氯
  • 方法一:2甲4氯的生产方法可概括为先缩合后氯化和先氯化后缩合2种。两种方法各有优缺点,先缩合后氯化生产原理如下。 缩合 于100~105℃ 反应1h,缩合反应即完成。 酸化 用盐酸调节pH值至5左右,于90~95℃进行脱酚处理。 氯化 加盐酸调节pH值1~2,于60
  • TCI Shanghai:(4-氯-2-甲基苯氧基)乙酸 (4-Chloro-2-methylphenoxy)acetic Acid,>;98.0%(T)(94-74-6)
  • 毒性分级:中毒
  • 方法一:2甲4氯的生产方法可概括为先缩合后氯化和先氯化后缩合2种。两种方法各有优缺点,先缩合后氯化生产原理如下。 缩合 于100~105℃ 反应1h,缩合反应即完成。
  • 急性毒性:口服- 大鼠 LD50: 700 毫克/公斤; 口服- 小鼠 LD50: 439 毫克/公斤
  • 用途二:激素型选择性除草剂,易为根部和叶部吸收传导。用于水稻等禾本科作物田间,芽后防除多种一年生或多年生阔叶杂草和某些单子叶杂草。对杀灭阔叶草及三梭草有特效,但对稗草类杂草无效。使用剂量为0.28~2.25kg有效成分/hm 2 。对棉花、黄豆、瓜菜等阔叶作物有影响。
  • 方法二:由邻甲酚经缩合、酸化、氯化而得。将26.24kg邻甲酚、13.9kg水、35%的氢氧化钠溶液27.37kg投入缩合锅内,在70℃以下搅拌配合成邻甲酚钠盐。在21.88kg氯乙酸和41.66kg水中,在25℃以下慢慢加入35%的氢
  • 用途四:该品商品为2-甲-4-氯钠盐,加工成20%水剂。为激素型除草剂,易为根和叶部吸收和传导,破坏植物的新陈代谢,致使植物变型;肿裂霉烂而死亡。适用于消灭禾木科作物,如小粒谷物、水稻、豌豆、草坪中的杂草,防除多种一年生和多年生双子叶宽叶杂草和某些单子叶杂草,使用剂量为0.28-2.25kg(有效成分)/hm2。对杀出阔叶草及三凌草等也有特效。该品对棉花、黄豆、瓜菜等阔叶作物影响很大,喷药后会死亡。该品不能与酸性能要混用。
  • 储运特性:库房通风低温干燥; 与食品原料分开储运
  • 外观性质:无色无味结晶。
  • 用途三:该品商品为2-甲-4-氯钠盐,加工成20%水剂。为激素型除草剂,易为根和叶部吸收和传导,破坏植物的新陈代谢,致使植物变型、肿裂霉烂而死亡。适用于消灭禾木科作物,如小粒谷物、水稻、豌豆、草坪中的杂草,防除多种一年生和多年生双子叶宽叶杂草和某些
  • MOL 文件:94-74-6.mol
  • Sigma Aldrich:94-74-6(sigmaaldrich)
  • 用途三:该品商品为2-甲-4-氯钠盐,加工成20%水剂。为激素型除草剂,易为根和叶部吸收和传导,破坏植物的新陈代谢
  • 2-甲基-4-氯苯氧乙酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 C0206 (4-氯-2-甲基苯氧基)乙酸 (4-Chloro-2-methylphenoxy)acetic Acid 500G 1100元 2014/06/02 C0206 (4-氯-2-甲基苯氧基)乙酸 (4-Chloro-2-methylphenoxy)acetic Acid 25G 98元
  • 溶于有机溶剂,在水中溶解度为825ppm。
  • 方法一:2甲4氯的生产方法可概括为先缩合后氯化和先氯化后缩合

系列性分类


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