CAS 79-01-6 MFCD00000838-Trichloroethylene 三氯乙烯 -LabNovo

Trichloroethylene 三氯乙烯

CAS 79-01-6 MFCD00000838

化学结构图

SMILES: ClC=C(Cl)Cl

化学属性

Mol. Formula	C2HCl3
Mol. Weight	131.39
Density	1.46
Refractive index	1.476-1.478
Autoignition Point	770 °F
Vapor Density	4.5 (vs air)
Boiling Point	87
Vapor Pressure	61 mmHg ( 20 °C)
Melting Point	-86
Flash Point	None
Solubility	Miscible with ether, alcohol, chloroform
TSCA	Yes
Stability	对光线敏感
pH	:A

别名和识别编码

Chemical Name	Trichloroethylene
Synonym	Trichloroethylene {LY} Trichloroethylene Trichloräthylen Tricloretene Triklo trichlorethene trichloroethene trichloroethylene trichloroethylene (INN) {} {LY} Trichloroethylene {} {} {LY} Trichloroethylene {} {} {} {LY} Trichloroethylene {} {} {} {} {LY} Trichloroethylene {} {} {} {} {} {LY} Trichloroethylene {} {} {} {} {} {} {LY} Trichloroethylene {} {} {} {} {} {} {} {LY} Trichloroethylene {} {} {} {} {} {} {} {} {LY} Trichloroethylene {} {} {} {} {} {} {} {} {} {LY} Trichloroethylene {} {} {} {} {} {} {} {} {} {} {LY} Trichloroethylene {} {} {} {} {} {} {} {} {} {} {} {LY} Trichloroethylene {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} Trichloroethylene {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Trichloroethylene {} {} {} {} {} {} {} {} {} {} {
CAS Number	79-01-6
EC Number	201-167-4
Beilstein Registry Number	1736782
MDL Number	MFCD00000838
Merck Number	9639
PubChem Substance ID	6575
Reaxys-RN	1736782
Chemical Name Translation	三氯乙烯
Wiswesser Line Notation	GYGU1G
LabNetwork Molecule ID	LN00164587
InChI	InChI=1S/C2HCl3/c3-1-2(4)5/h1H
Canonical SMILES	Cl/C(Cl)=C/Cl

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产品应用

用作不燃性溶剂、测定碘价、有机合成。

安全信息

Signal word Danger

GHS Symbol

WGK Germany3

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；

Risk Statements

R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性：吸入，皮肤接触和吞食都会产生十分严重的不可逆危险
R45 May cause cancer 可能致癌
R52/53
R67 Vapours may cause drowsiness and dizziness 蒸汽可能导致嗜睡和昏厥
R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P302+P352
P303+P361+P353
P304+P340
P305+P351+
P305+P351+P338
P308+P313
P405 Store locked up. 上锁保管。

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H336 May cause drowsiness or dizziness 肯能导致嗜睡或头晕
H350 May cause cancer 可能致癌
H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
H319 Causes serious eye irritation 严重刺激眼睛
H225 Highly flammable liquid and vapour 高度易燃液体和蒸气

Personal Protective Equipment Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

RTECSKX4550000

Packing GroupIII

UN Number 1710 UN 1710 6.1/PG 3 UN1710

Hazard Codes 6.1 T

Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {

Hazard Class3/6.1

TYPE OF TEST            : TCLo - Lowest published toxic co

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 455 gm/kg/78W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/pag

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 100 ppm/6H/77W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Blood - lymphoma, including Hodgkin's disease
   Liver - tumors
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   43,237,1980

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 515 gm/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
   Blood - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year:

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 912 gm/kg/78W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-2,1976

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 110 ppm/8H
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Behavioral - hallucinations, distorted perceptions
REFERENCE :
   BJIMAG British Journal of Industrial Medicine.  (British Medical Journal,
   Box 560B, Kennebunkport, ME 04046)  V.1-    1944-  Volume(issue)/page/year:
   28,293,1971

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 2900 ppm
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NZMJAX New Zealand Medical Journal.  (New Zealand Medical Assoc., P.O. Box
   156, Wellington, New Zealand)  V.1-    1900-  Volume(issue)/page/year:
   50,119,1951

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Human
DOSE/DURATION           : 812 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - other changes
   Liver - jaundice, other or unclassified
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   2,689,1945

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Human
DOSE/DURATION           : 6900 mg/m3/10M
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - hallucinations, distorted perceptions
REFERENCE :
   AHBAAM Archiv fu

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 40 mmol/L
REFERENCE :
   JEPTDQ Journal of Environmental Pathology and Toxicology.  (Park Forest
   South, IL)  V.1-5(3), 1977-81(?).  For publisher information, see JEPOEC.
   Volume(issue)/page/year: 1(4),411,1978

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - hamster Fibroblast
DOSE/DURATION           : 1 pph
REFERENCE :
   ANESAV Anesthesiology.  (Lippincott/Harper, Journal Fulfillment Dept., 2350
   Virginia Ave., Hagerstown, MD 21740)  V.1-    1940- Volume(issue)/page/year:
   43,21,1975

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human Lung
DOSE/DURATION           : 100 mg/L
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB82-185075

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 22 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 206,209,1988

TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 18 ug/well
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 260,349,1991

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 5 mL/L
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 150 ppm/24H
SEX/DURATION            : male 4 week(s) pre-mating
                          female 4 week(s) pre-mating  - 3 week(s) after
                          conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1977-  Volume(issue)/page/year: 23,223,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2688 mg/kg
SEX/DURATION            : female 1-22 day(s) after conception
                          lactating female 21 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(

{hazard_com

TYPE OF TEST            : TDLo - Lowest

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1800 ppm/24H
SEX/DURATION            : female 1-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   APTOD9 Abstracts of Papers, Society of Toxicology.  A

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 36 gm/kg
SEX/DURATION            : female 15 day(s) pre-mating

Warnings 危险化学品

其他信息

用途五:用作不燃性溶剂、测定碘价、有机合成。
用途二:用于制造靛蓝及其他染料，生产一氯代乙酸，是重要的工业溶剂，用作金属洗涤剂、干洗剂、农用杀虫剂等
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毒性分级:中毒
常规方法:以镀锌铁桶密闭包装，存放于阴凉通风处。贮运时注意防火、防晒、防止撞击。
储运特性:库房通风低温干燥; 与食品添加剂分开存放
{Chemica
用途三:萃取溶剂。主要用于咖啡的脱咖啡因等，其在磨粒咖啡成品中的最高允许残留量为25mg/kg，在速溶咖啡中为10mg/kg，在香辛料油树脂中为30mg/kg。
下游产品:氯乙酸 --> 清洗剂 --> 六甲基磷酰三胺 --> 乐果 --> 杀虫畏 --> 四氯乙烯 --> 敌敌畏 --> 六氯乙烷 --> 1,2-亚乙基硫脲 --> 邻苯基苯酚 --> 二氯乙酰氯 --> 辣椒红 --> 喷托维林 --> 硫氯酚 --> 叶绿素 A --> 对羟基联苯 --> 4-氨基-6-甲氧基嘧啶 --> 四氯环丙烯 --> 叶绿酸铜钠 --> 八氯二丙醚 --> 五氯乙烷 --> 异丙净 --> 1,1,1-三氯三氟乙烷 --> 邻苯基苯酚钠 --> 西玛津 --> 3-甲基-4-异丙基苯酚 --> 磺胺间甲氧嘧啶 --> 2,4,6-三氟苯基异硫氰酸酯 --> 磺胺间二甲氧嘧啶钠
防护措施:有麻醉
爆炸物危险特性:与空气混合可爆
MOL 文件:79-01-6.mol
有氯仿样的特殊气味，不燃、低粘度。在潮湿空气中能被光线缓慢分解生成盐酸。能与醇、醚和氯仿混和，能溶于多数油类，几乎不溶于水。药用常加入百里香酚或碳酸铵作稳定剂。工业上常用三乙醇胺、硬酯酸酯或甲酚作稳定剂。
方法二:1.乙炔法此法以电石发生的乙炔和氯气为原料、四氯化碳为稀释剂、三氯化铁为催化剂液相合成1,1,2,2-四氯乙烷，再加石灰乳脱氯化氢，得粗三氯乙烯，经粗馏、精馏，即得产品。因乙炔价昂，大多转用乙烯法。2.乙烯直接氯化法经直接氯化得四氯乙烷和五氯乙烷的混合物，通过对其进行气相裂解制取三氯乙烯和四氯乙烯。3.乙烯氧氯化法此法以乙烯、氧气
Acros Organics:三氯乙烯 Trichloroethylene, stabilized, extra pure, 99+%(79-01-6)
毒性:FAO/WHO(2001)：ADI未作规定(以工艺需要的最低量为限)。 LD 50 3670mg/kg(大鼠，经口)。
可燃性危险特性:受热或遇明火可燃；燃烧放出有毒氯化物
{C
用途四:优良的溶剂，用作金属表面处理剂，电镀、上漆前的清洁剂，金属脱脂剂和脂肪、油、石蜡的萃取剂。用于有机合成、农药的生产。三氯乙烯用于生产四氯乙烯可作为驱肠虫药；用于生产六氯乙烷，作为兽用驱虫药，来用防治反刍兽类肝蛭病及胃蛭病、睾吸虫病和线虫病。
刺激数据:皮肤-兔子 2 毫克/
蒸气压:61 mm Hg ( 20 °C)
Alfa Aesar:无水三氯乙烯,anhydrous,99+%,packagedunderArgoninreseal
Sigma Aldrich:79-01-6(sigmaaldrich)
海关编码:29032200
方法一:由四氯乙烷在水的存在下，与石灰或碱作用或进行热分解，然后经水蒸气蒸馏而得。
TCI Shanghai:三氯乙烯(1mg/ml的甲醇溶液)[用于水分析] Trichloroethylene (1mg/ml in Methanol) [for Water Analysis](79-01-6)
类别:农药
蒸气密度:4.5 (vs air)
参考质量标准:FAO/WHO，1992(暂定) 馏程 85～88℃ 不挥发残渣(OT-39) 20mg/kg 酸度试验阴性游离氯试验阴性氯化物试验阴性炔属化合物试验阴性碳酰氯试验阴性