1-Fluoro-2,4-dinitrobenzene 2,4-二硝基氟苯

CAS 70-34-8 MFCD00007056


SMILES: O=[N+]([O-])c1ccc(F)c([N+](=O)[O-])c1


Mol. FormulaC6H3FN2O4
Mol. Weight186
Refractive indexn20/D 1.569(lit.)
Boiling Point178
Melting Point25-27
Flash Point>110°(230°F)
Solubility400 MG/L (25 ºC)


Chemical Name2,4-Dinitrofluorobenzene
Synonym 1 Fluoro 2,4 dinitrobenzene 1,3-Dinitro-4-fluorbenzol 1-Fluor-2,4-dinitrobenzol 1-Fluoro-2,4-dinitro-benzene 1-Fluoro-2,4-dinitrobenzene 1-Fluoro-2,4-dinitrobenzene; 2,4-Dinitro-1-fluorobenzene; DNFB 1-​Fluoro-​2,4-​dinitrobenzene 1-氟-2,4-二硝基苯 2,4-DINITRO-1-FLUOROBENZENE 2,4-DINITROFLUOROBENZENE 2,4-Dinitro-1-fluorobenzene 2,4-Dinitrobenzene fluoride 2,4-Dinitrofluorobenzene 2,4-dinitro-1-fluoro-benzen 4-Fluoro-1,3-dinitrobenzene Benzene, 1-fluoro-2,4-dinitro- Benzene, 2,4-dinitro-1-fluoro- DFB DNF DNF OR DNFB DNFB Dinitrofluorobenzene FDNB Fluoro-2,4-Dinitrobenzene Fluorodinitrobenzene Sanger's Reagens {} {Chemicalbook {} {} {
CAS Number70-34-8
PubChem Substance ID6264
EC Number200-734-3
Beilstein Registry Number398632
MDL NumberMFCD00007056
Merck Number4172
Chemical Name Translation2,4-二硝基氟苯
Wiswesser Line NotationWNR BF ENW
LabNetwork Molecule IDLN00188567
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   


  • {SNA} α-aminocarboxylic Acids, Amino Acid Analysis, Amino Acid Analysis Reagents, Amino Acids, Analytical Reagents, Analytical/Chromatography, Biochemicals and Reagents, Derivatization Reagents, Derivatization Reagents HPLC, Fluorescence, HPLC Derivatization Reagents, by Application, Halogenated, Peptide Analysis and Characterization, Peptides, UV-VIS
  • Activity, Biochemicals and Reagents, Enzyme Substrates, Enzymes, Inhibitors, and Substrates, Fluorogenic
  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; 1fragment
  • {SNA} Activity, Enzyme Substrates, Fluorogenic, 生化试剂, 酶、抑制剂和底物


  • Merck 14 ,4172
  • Beil. 5 ,IV,742
  • Aldrich MSDS 1 , 815:B / Corp MSDS 1 (1), 1437:D / FT-IR 1 (1), 1369:D / FT-IR 2 (2), 2312:D / FT-NMR 1 (2), 749:C / IR-Spectra (3), 827:F / IR-Spectra (2), 725:D / NMR-Reference 2 (1), 1173:C / RegBook 1 (1), 1587:E / Sax 6 , 1214 / Sigma FT-IR 1 (2), 516:C / Structure Index 1 , 247:B:6 / Vapor Phase 3 , 1212:B
  • Short: III/35E Title: Nuclear Magnetic Resonance (NMR) Data: Chemical Shifts for Oxygen-17 Author: Duddeck, H.; Toth, G.; Simon, A. Editor: Gupta, R.R.; Lechner, M.D. Source: Landolt-Börnstein, New Series Volume: III/35E Year: 2002 Keyword: Alipathic and Aromatic hydrocarbons; Coupling constant j; Nuclear Magnetic Resonance; chemical shifts δ ISBN: 3-540-42501-2 ISBN: 978-3-540-42501-4 I
  • The activated fluoro-substituent is readily displaced by nucleophiles under mild conditions. The anomeric center of a carbohydrate has been protected as the 2,4-dinitrophenyl ether in the presence of DABCO in DMF: Rec. Trav. Chim., 99, 355 (1980).
  • Used for labelling terminal amino acids in peptides: Biochem. J., 45, 563 (1949); Biochemistry, 20, 512 (1981).
  • Has been used as a means of protection for the thiol group. The resulting thioether can be cleaved quantitatively with 2-mercaptoethanol: Biochem. Biophys. Res. Commun., 29, 178 (1967).
  • Can also be used for the masking of the imidazole ring in histidine as the 2,4-dinitrophenyl derivative during peptide synthesis, introduced in the presence of, e.g. K2CO3: Biochem. Biophys. Acta., 82, 412 (1964). The group can be cleaved by treatment with thioglycolic acid, mercaptoethanol, dithiothreitol or thiophenol: Biochem. Biophys. Res. Commun., 29, 178 (1967); Biochemistry, 9, 5122 (1970). The electron withdrawing character of the group has been shown to reduce racemization promoted by the imidazole function: J. Biol. Chem., 247, 4768 (1972). See Appendix 6.


GHS Symbol
WGK Germany3
Hazard Codes 6.1 C,T T;C Xn
Hazard statements
  • H300 Fatal if swallowed 吞食致命
  • H301 Toxic if swallowed 吞食有毒
  • H302 Harmful if swallowed 吞食有害
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H315 Causes skin irritation 会刺激皮肤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H318 Causes serious eye damage 严重伤害眼睛
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H330 Fatal if inhaled 吸入致命
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P301+P310
  • P301+P310+P330
  • P301+P312
  • P301+P316
  • P301+P317
  • P302+P352
  • P302+P352+P333+P313+P362+P364
  • P304+P340
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P305+P354+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医,如果你觉得不舒服
  • P316
  • P317
  • P319
  • P320 Specific treatment is urgent (see … on this label). 紧急具体治疗(见本标签上的)。
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P322 Specific measures (see …on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P332+P317
  • P333+P313
  • P337+P313
  • P337+P317
  • P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
  • P361+P364
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P362+P364
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger Warning
UN Number 2811 UN 3261 8/PG 2
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
  • R33 Danger of cumulative effects 有累积作用的危险
  • R34 Causes burns 会导致灼伤
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R38 Irritating to skin 刺激皮肤
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
  • R42/43
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
  • R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘;
  • S24 Avoid contact with skin 避免皮肤接触;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后,立即用大量…(由生产厂家指定)冲洗;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
Packing GroupII
Hazard Class6.1
Storage condition 2-8°C
Restrict {} 剧毒化学品 危险品
Warnings 危化品目录(2015)
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
   Details of toxic effects not reported other than lethal dose value
   BIJOAK Biochemical Journal.  (Biochemical Soc. Book Depot, POB 32, Commerce
   Way, Colchester, Essex CO2 8HP, UK)  V.1-    1906- Volume(issue)/page/year:

TYPE OF TEST            : LDLo - Lowest published lethal dose
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 50 mg/kg
   Details of toxic effects not reported other than lethal dose value
   NCNSA6 National Academy of Sciences, National Research Council,
   Chemical-Biological Coordination Center, Review.  (Washington, DC)
   Volume(issue)/page/year: 5,17,1953

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
   Details of toxic effects not reported other than lethal dose value
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Kidney
DOSE/DURATION           : 80 ug/L
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 33 ug/plate
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 5(Suppl

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 10 mg/well/16H
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 5 umol/L
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 3,139,1982

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 5 ug/plate
   SAIGBL Sangyo Igaku.  Japanese Journal of Industrial Health.  (Nippon Sangyo
   Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160,
   Japan)  V.1-    1959-  Volume(issue)/page/year: 29,34,1987

TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 320 umol/L
   MGGEAE Molecular and General Genetics.


  • 可燃性危险特性:明火可燃;受热分解放出氮氧化物和氟化物
  • 下游产品:2,4-二氯氟苯
  • 类别:农药
  • 毒性分级:高毒
  • Sigma Aldrich:70-34-8(sigmaaldrich)
  • MOL 文件:70-34-8.mol
  • Alfa Aesar:2,4-二硝基-1-氟苯,99% 1-Fluoro-2,4-dinitrobenzene, 99%(70-34-8)
  • 方法一:以2,4-二硝基氯苯与无水氟化钾为原料,经亲核取代反应而得。
  • 上游原料:2,4-二硝基氯苯
  • Hazard Note:Toxic
  • 用途二:本品可制成2,4-二氯氟苯,后者是合成环丙沙星、培氟沙星、二氟沙星等喹喏酮类抗菌药的起始原料。本品也是一种重要的分析试剂,用来鉴定有机化合物中的氨基,尤其是用于检定肽及蛋白质末端氨基酸的氨基。检定时,2,4-二硝基氟苯与肽链的游离氨基作用,生成2,4-二硝基衍生物。将其水解后,末端氨基酸的N-(2,4-二硝基苯基)衍生物常为亮黄色结晶,易与其他氨基酸分离。用该方法结合其他方法,可确定蛋白质或多肽氨基端碳链的结构,称桑格法。本品也用于测定酚和咖啡,以及醛糖分析。
  • 2,4-二硝基氟苯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80056216 2,4-二硝基氟苯(剧毒)(阴凉) 100g 350元 2010/06/21 117030050 2,4-二硝基氟苯 2,4-Dinitrofluorobenzene 98% 5 GR 236元 2010/06/21 117030250 2,4-二硝基氟苯 2,4-Dinitrofluorobenzene 98% 25 GR 697元
  • 急性毒性:口服-大鼠 LDL0: 50 毫克/公斤; 皮下-小鼠 LDL0: 100 毫克/公斤
  • 海关编码:29049085
  • 储运特性:库房通风低温干燥; 与还原剂、食品添加剂分开存放
  • Acros Organics:2,4-二硝基氟苯 2,4-Dinitrofluorobenzene, 98%(70-34-8)
  • MSDS 信息:2,4-二硝基-1-氟苯(70-34-8).msds
  • 外观性质:黄色针状结晶, 液化后为澄黄色液体。
  • 灭火剂:泡沫、二氧化碳、干粉、砂土。
  • 用途一:用作医药、农药、染料中间体