Diethylaminosulfur trifluoride 二乙胺基三氟化硫

CAS 38078-09-0 MFCD00000363

化学结构图

38078-09-0
SMILES: CCN(CC)S(F)(F)F

化学属性

Mol. FormulaC4H10F3NS
Mol. Weight161.19
Boiling Point114.4°C at 760 mmHg
Density1.316
Refractive index1.41-1.416
Flash Point23.9°C
TSCANo
Melting PointN/A
pH:A

别名和识别编码

Chemical NameDiethylaminosulfur trifluoride
CAS Number38078-09-0
Alfabeta NameDIETHYLAMINOSULFURTRIFLUORIDE
MDL NumberMFCD00000363
Synonym Diethylaminosulfur trifluoride {LY} Diethylaminosulfur trifluoride {} {LY} Diethylaminosulfur trifluoride {} {} {LY} Diethylaminosulfur trifluoride {} {} {} {LY} Diethylaminosulfur trifluoride {} {} {} {} {LY} Diethylaminosulfur trifluoride {} {} {} {} {} {LY} Diethylaminosulfur trifluoride {} {} {} {} {} {} {LY} Diethylaminosulfur trifluoride {} {} {} {} {} {} {} {LY} Diethylaminosulfur trifluoride {} {} {} {} {} {} {} {} {LY} Diethylaminosulfur trifluoride {} {} {} {} {} {} {} {} {} {LY} Diethylaminosulfur trifluoride {} {} {} {} {} {} {} {} {} {} {LY} Diethylaminosulfur trifluoride {} {} {} {} {} {} {} {} {} {} {} {LY} Diethylaminosulfur trifluoride {} {} {} {} {} {} {} {} {} {} {} {} {LY} Diethylaminosulfur trifluoride {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Diethylaminosulfur trifluoride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Diethylaminosulfur trifluoride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
EC Number253-771-2
Beilstein Registry Number1849066
PubChem Substance ID87568332
Reaxys-RN1849066
Merck Number3113
Chemical Name Translation二乙胺基三氟化硫
LabNetwork Molecule IDLN00010705
Canonical SMILESCCN(S(F)(F)F)CC
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分类

  • {SNA} Chemical Synthesis, Fluorination, Fluorination Reagents, Synthetic Reagents
  • Intermediates
  • Miscellaneous Reagents
  • {uni_hamburg} no charge; 1fragment

产品应用

  • 氟化试剂

相关文献及参考

  • In the presence of SbCl3, promotes the fluoro-Pummerer rearrangement of sulfoxides: J. Am. Chem. Soc., 107, 735 (1985); Org. Synth. Coll., 9, 446 (1998):
  • See also 4-Morpholinyl­sulfur trifluoride, L19751.
  • Giannini, G. et al.: Eur. J. Org. Chem., 11, 2411 (2004); Lafargue, P. et al.: Synlett, 2, 171 (1995);
  • Direct conversion of thioethers to the ɑ-fluoro analogues has also been reported: J. Org. Chem., 58, 3800 (1993). Fluorination of thioesters leads to ɑɑ-difluoroethers: J. Org. Chem., 55, 768 (1990):
  • Short: III/35B
  • Short: IV/20C
  • Convenient reagent for conversion, in the absence of base, of N-protected amino acids to the acyl fluorides: Lett. Pept. Sci., 2, 285 (1996); Indian J. Chem., 39, 384 (2000); compare Cyanuric fluoride, A15666. Review of peptide coupling via amino acid halides: Acc. Chem. Res., 29, 268 (1996). See also Appendix 6.
  • Use of dichloromethane as solvent permits the selective monofluorination of sugars: J. Org. Chem., 48, 393 (1983). Glycosyl fluorides, which are useful building blocks for oligosaccharides: J. Am. Chem. Soc., 105, 2430 (1983), and C-glycosides, can be prepared by reaction of DAST with phenylthioglycosides: J. Am. Chem. Soc., 106, 4189 (1984). The reaction with diols can lead to difluorides, sulfite esters or cyclic ethers: J. Chem. Soc., Perkin 2, 861 (1995).
  • Reagent for conversion of alcohols to alkyl fluorides and carbonyl compounds to gem-difluorides, less prone to cause dehydration or rearrangement than SF4: J. Org. Chem., 40, 574 (1975); Org. Synth. Coll., 6, 835 (1988); Eur. J. Org. Chem., 3177 (2000); Tetrahedron Lett, 44, 6661 (2003); reviews: Org. React., 35, 513 (1988); Austral. J. Chem., 54, 75 (2001); Synlett, 1130 (2006). Conversion of alcohols to fluorides has been accomplished with stereocontrol at the chiral center: Tetrahedron: Asym., 4, 161 (1993).
  • Short: IV/20A

安全信息

Warnings KEEP COLD, FLAMMABLE, CORROSIVE
Packing GroupI
UN Number 2920
Risk Statements
  • R10 Flammable 易燃
  • R14 Reacts violently with water 遇水会猛烈反应
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R34 Causes burns 会导致灼伤
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S30 Never add water to this product 切勿将水加入该产品中；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Storage condition -20°C, stored under nitrogen {LY} -20°C, stored under nitrogen 0-10 0-10°C 2-8°C充氩密封保存 Moisture Sensitive {} {LY} -20°C, stored under nitrogen {} {} {LY} -20°C, stored under nitrogen {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -2
GHS Symbol
WGK Germany3
Hazard statements
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H302+H312+H332
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P303+P361+P353+P310+P363
  • P304+P340
  • P305+P351+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Hazard Codes 8 C
Hazard Class8/3

其他信息

  • 见水分解。

系列性分类

  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Fluorination Reagents 含氟试剂
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. C-X Bond Formation (Halogen) 卤代烃
  4. Chlorination - C-X Bond Formation (Halogen)
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Sulfur Compounds 硫化合物
  5. Thiols/Mercaptans - Sulfur Compounds
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Halogenation

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