Formic acid 甲酸

CAS 64-18-6 MFCD00003297

化学结构图

64-18-6
SMILES: O=[C]O

化学属性

Mol. FormulaCH2O2
Mol. Weight46
Refractive index1.3690 to 1.3730
Autoignition Point1004 °F
Vapor Density1.6 (vs air)
Boiling Point100-101
Vapor Pressure44.8 mmHg ( 20 °C)
Density1.22
Melting Point8
Flash Point57°C(lit.)
TSCAYes
SolubilityMISCIBLE
Stability对湿度敏感
pH:A

别名和识别编码

Chemical NameFormic acid
Synonym Kwas metaniowy Kyselina mravenci Formylic acid 无水甲酸 蚁酸 Ameisensaeure 甲酸 溶液 Mierenzuur Methanoic acid 甲酸; Acido formico 甲酸 Acide formique 甲酸, 85% Formic acid Aminic acid RCRA waste number U123 甲酸根,用于离子色谱标准液 Hydrogen carboxylic acid
MDL NumberMFCD00003297
CAS Number64-18-6
PubChem Substance ID284
EC Number200-579-1
Beilstein Registry Number2(4)3
Merck Number4241
Chemical Name Translation甲酸
Reaxys-RN1209246
InChIKeyBDAGIHXWWSANSR-UHFFFAOYSA-N
Wiswesser Line NotationVHQ
LabNetwork Molecule IDLN00193468
InChIInChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • {SNA} Chromatography Reagents & Solvents, HybridSPE-Phospholipid Technology, LC-MS Mobile Phase Additives, LC-MS Solvents & Reagents (CHROMASOLV), Precipitation Solvents, Blends, Additives, Sample Preparation & Purification, Solid Phase Extraction (SPE), 分析/色谱, 分析试剂
  • {S
  • {SNA} Analytical Standards,
  • {SNA} Chromatography Reagents & Solvents, UHPLC-MS Mobile Phase Additives, UHPLC-MS and UHPLC-UV Solvents, Additives and Blends (Application tested), 分析/色谱, 分析试剂
  • {SNA} Acids, Acids & Bases, Analytical Reagents, Analytical/Chromatography, Buffers & Reagents, Chemical Synthesis, Chromatography Reagents & Solvents, HPLC, HPLC Buffers,
  • {SNA}
  • {SNA} Acids, Acids & Bases,

产品应用

  • 还原剂,测定砷、铋、铝、铜、金、铟、铁、铅、锰、汞、钼、银和锌等,检定铈,铼和钨,检验芳香族伯胺和仲胺,测定分子量及结晶的溶剂,测定甲氧基,显微分析中用作固定剂,制造甲酸盐类。

相关文献及参考

  • In the presence of Raney nickel alloy, reduces aromatic nitriles to aldehydes in high yield: J. Chem. Soc., 5775 (1965); for list of examples, see: Org. Synth. Coll., 6, 631 (1988).
  • Merck: 14,4241 Beilstein:2(4)3
  • Merck: 14,4241
  • Dehydration with sulfuric acid can be used to generate CO in situ. Subsequent reaction with tertiary carbocations gives the corresponding carboxylic acid (the Koch-Haaf carboxylation). For examples, see: Org. Synth. Coll., 5, 20, 739 (1973); improved procedure: Synth. Commun., 19, 1945 (1989). 1,4-Diols in which one alcohol is tertiary give -lactones: Che
  • Used in combination with formaldehyde in the Eschweiler-Clarke reductive methylation of amines, the formic acid acting as a hydride donor. Review: Org. React., 5, 290 (1949). For an example, see: Org. Synth. Coll., 3, 723 (1955).
  • In combination with Selenium(IV)­ oxide, 12358, improved results have been obtained in the allylic oxidation of sterically-hindered olefins: Synth. Commun., 24, 29213 (1994).
  • Instead of the unstable formic anhydride, formylations may be carried out with formic acid and acetic anhydride to generate the mixed acetic formic anhydride in situ. For a review, see: Tetrahedron, 46, 1081 (1990). This reagent has been used for the deoxygenation of tertiary amine oxides: Chem. Lett., 1517 (1985).
  • Cleaves trityl groups selectively in the presence of benzylidene acetals or TBDMS ethers: T
  • Hydrogen donor, in combination with Pd on carbon, in catalytic transfer hydrogenations; see, e.g.: Selective reduction of dinitroarenes to nitroanilines: J. Org. Chem., 45, 4992 (1980). Dehalogenation of aryl halides: Synthesis, 876 (1982). Hydrogenation of aromatic rings: Tetrahedron Lett., 33, 7477 (1992). See also Palladium, A12012, Cyclohexene, A11359, and Ammonium formate, A10699. For a comparative mechanistic study of formic acid and formate salts in hydrogenolysis of aryl chlorides, see: J. Org. Chem., 60, 1347 (1995).

安全信息

GHS Symbol
WGK Germany1
Hazard statements
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H331 Toxic if inhaled 吸入中毒
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
Personal Protective Equipment Eyeshields, Gloves Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSLQ4900000
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312+P330
  • P303+P361+P353
  • P304+P340+P310
  • P305+P351+P338
  • P305+P351+P338+P310
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P403+P233
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Packing GroupII
UN Number 1779 UN1779
Risk Statements
  • R10 Flammable 易燃
  • R34 Causes burns 会导致灼伤
  • R35 Causes severe burns 会导致严重灼伤
Safety Statements
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
Storage condition 密封保存 充氩保存 Hygroscopic
Hazard Codes 8 C
Hazard Class8/3
Warnings 危化品目录(2015)
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 15 gm/m3/15M
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co.,
   1956-59  Volume(issue)/page/year: 1,146,1955

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 15 gm/m3/15M
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 23(12),49,1979

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 239 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Sa

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF E

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Non-mammalian species Cells - not otherwise specified
DOSE/DURATION           : 100 mmol/L
REFERENCE :
   CAANAT Comptes Rendus de l'Association des Anatomistes.  (Nancy, France)
   V.1-56, 1899-1972.  For publisher information, see ANOBAU.
   Volume(issue)/page/year: 56,712,1972

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 10 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 240,195,1990

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Inhalati

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 70 ppm/3H
REFERENCE :
   AMNTA4 American Naturalist.  (Univ. of Chicago Press, Journals Div., POB
   37005, Chicago, IL 60637) V.1-    1867-  Volume(issue)/page/year:
   85,119,1951

TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 100 mmol/L
REFERENCE :
   MDMIAZ Medycyna Doswiadczalna i Mikrobiologia.  For English translation, see
   EXMMAV.  (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland)  V.1-    1949-
   Volume(issue)/page/year: 31,11,1979

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Non-mammalian species Cells - not otherwise specified
DOSE/DURATION           : 100 mmol/L
REFERENCE :
   CAANAT Comptes Rendus de l'Association des Anatomistes.  (Nancy, France)
   V.1-56, 1899-1972.  For publisher information, see ANOBAU.
   Volume(issue)/page/year: 56,712,19

Restrict 危险品

其他信息

  • 能与水、醇、醚和甘油任意混合,对皮肤有腐蚀性。
  • 具有刺激性气味,能与水、醇、醚、丙三醇相混合.

系列性分类


相关产品推荐