Hexamethylenetetramine 乌洛托品,无水(易制爆)

CAS 100-97-0 MFCD00006895

化学结构图

100-97-0
SMILES: C1N2CN3CN1CN(C2)C3

化学属性

Mol. FormulaC6H12N4
Mol. Weight140.19
Melting Point280 °C (subl.)(lit.)
Density1.331
Flash Point250°(482°F)
TSCAYes
Autoignition Point770 °F
Vapor Pressure<;0.01 mmHg ( 20 °C)
Solubility溶于水、乙醇、氯仿、四氯化碳，不溶于乙醚、石油醚、芳烃。
Stability对湿度敏感

别名和识别编码

Chemical NameHexamethylenetetramine
CAS Number100-97-0
Synonym ######## 1,3, 1,3,5,7-T 1,3,5,7-Tetraaza-tricyclo[3.3.1.13,7]decane 1,3,5,7-Tetraazaadamantane 1,3,5,7-Tetraazatricyclo(3.3.1.1(sup 37))decane 1,3,5,7-Tetraazatricyclo[3.3.1.1(3,7)]-d 1,3,5,7-Tetraazatricyclo[3.3.1.13,7]-decane 1,3,5,7-Tetraazatricyclo[3.3.1.13,7]decane 1,3,5,7-四氮杂三环[3.3.1.13,7]癸烷 六亚甲基四胺 六胺 环六亚甲基四胺 AMINOFORM AMMONIOFORMALDEHYDE Aceto HMT Aminoform Ammoform Antihydral CYSTOGEN Cystam Cystogen Duirexol Ekagom H Esametilentetramina Formamine Formin Formin (the heterocyclic compound) HA HEXAMETHYLENETETRAMINE Heterin {uni_hamburg}
Beilstein Registry Number2018
PubChem Substance ID4101
EC Number202-905-8
MDL NumberMFCD00006895
Merck Number14,5966
Chemical Name Translation乌洛托品,无水(易制爆)
Wiswesser Line NotationT66 B6 A B- C 1B I BN DN FN HNTJ
InChIInChI=1S/C6H12N4/c1-7-2-9-4-8(1)5-10(3-7)6-9/h1-6H2
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • {Chemicalbook} 化工助剂: 纺织染整助剂: 纺织品后整理剂
  • {SNA} Analytical Reagents for General Use, E-H, Puriss p.a., Puriss p.a., 分析/色谱, 分析试剂
  • {uni_hamburg} no charge; nitrogen heterocycle; alicycle; large ring; fused rings; 6ring; 8ring; 1fragment
  • {SNA} Building Blocks, Chemical Synthesis, Heterocyclic Building Blocks, N-Containing, Others
  • Building Blocks, Chemical Synthesis, Nitrogen Compounds, Organic Building Blocks, Polyamines
  • {SNA} Pharmacopoeia, Pharmacopoeia A-Z, 分析/色谱

产品应用

  • 肝功能试验中配制麝香草酚浊度液，检定和测定物铋、铁、锰、钴、钍、铂和镁，检定锂、铁氰化物溴化物和碘化物，测定铜、铀、铍、碲等，气相色谱固定液(最高使用温度180℃，溶剂为氯仿)。

相关文献及参考

  • Day, G.M., et al.: J. Physical Chem., 107,?10919 (2003),
  • Merck:14,5966 Beilstein: 26,IV,1680
  • The reaction can also be carried out to give the primary amine on hydrolysis (Delepine reaction). For conversion of allylic halides to amines, see, e.g.: Org. Synth. Coll., 5, 121 (1973); 9, 666 (1998).
  • Formylation of arylamines and phenols in the presence of acid to give aldehydes (Duff reaction) generally gives low yields: J. Chem. Soc., 547 (1941); Org. Synth. Coll., 4, 866 (1963). In TFA, formylation of aromatic hydrocarbons occurs in good yield with para-selectivity: J. Org. Chem., 37, 3972 (1972). Careful control of reaction conditions enables 4-substituted phenols in TFA to be converted to either 2-formyl or 2,6-diformyl derivatives: Synthesis, 1029 (1998).
  • Benzylic halides form quaternary salts with hexamine which undergo oxidation during hydrolysis to give aldehydes (Sommelet reaction): Org. React., 8, 197 (1954); Org. Synth. Coll., 3, 811 (1955); 4, 690, 918 (1963). Benzylamines can also be converted to benzaldehydes; see e.g.: Org. Synth. Coll., 5, 668 (1973).
  • Can be used as a Mannich reagent, e.g. for the ɑ-methylenation of ketones: Synth. Commun., 26, 1775 (1996). For example with reaction scheme, see Propiophenone, A15140.
  • For a review of applications in organic synthesis, see: Synthesis, 161 (1979).
  • Short: II/27B
  • Merck:14,5966

安全信息

GHS Symbol
WGK Germany1
Hazard Codes F,Xn F,Xi
Hazard statements
  • H228 Flammable solid 易燃固体
  • H302 Harmful if swallowed 吞食有害
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
  • H351 Suspected of causing cancer 怀疑致癌
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
RTECSMN4725000
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P285 In case of inadequate ventilation wear respiratory protection. 在通风不足的情况下，戴呼吸防护。
  • P301+P312
  • P301+P330+P331
  • P302+P352
  • P303+P361+P353
  • P304+P340
  • P304+P341
  • P305+P351+P338
  • P308+P313
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P333+P313
  • P342+P311
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P370+P378
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Warning
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S24 Avoid contact with skin 避免皮肤接触；
  • S37 Wear suitable gloves 戴适当手套；
  • S22 Do not breathe dust 不要吸入粉尘；
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
  • S2 Keep out of the reach of children 避免儿童触及；
UN Number 1328 UN 1328 4.1/PG 3 1325/1328 UN1328
Risk Statements
  • R42/43
  • R11 Highly flammable 非常易燃
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
Storage condition Store at RT. 密封保存。 Hygroscopic
Packing GroupIII
Hazard Class4.1
Restrict 易制爆 {} 易制爆危险化学品
Warnings 危化品目录(2015) 危险化学品 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 140 gm/kg/78W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   FAONAU FAO Nutrition Meetings Report Series.  (Rome, Italy)  No.?-57,
   1948-77.  Discontinued.  Volume(issue)/page/year: 50A,71,1972

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 450 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IPSTB3 International Polymer Science and Technology.  (Rapra Technology
   Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK) Volume(issue)/page/year:
   3,93,1976

TYPE OF TES

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 17700 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ANTBAL Antibiotiki.  (Moscow, USSR)  V.1-29, 1956-84.  For publisher
   information, see AMBIEH.  Volume(issue)/page/year: 20,891,1975

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IPSTB3 International Polymer Science and Technology.  (Rapra Technology
   Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK) Volume(issue)/page/year:
   3,93,1976

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co.,
   1956-59  Volume(issue)/page/year: 1,84,1955

TYPE OF TEST            : LD50 -

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED

TYPE OF TEST            : Dominant lethal test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 25 gm/kg
REFERENCE :
   DMWOAX Deutsche Medizinische Wochenschrift.  (Stuttgart, Fed. Rep. Ger.)
   V.1-104, 1875-1979.  Volume(issue)/page/year: 92,2315,1967

TYPE OF TEST            : Dominant lethal test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 25 gm/kg
REFERENCE :
   HUMAA7 Humangenetik.  (Heidelberg, Fed. Rep. Ger.)  V.1-30, 1964-75.  For
   publisher information, see HUGEDQ.  Volume(issue)/page/year: 4,112,1967

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   HUMAA7 Humangenetik.  (Heidelberg, Fed. Rep. Ger.)  V.1

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 6 mg/well/16H
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   15,219,1976

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Kidney
DOSE/DURATION           : 10 mg/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 4,457,1983

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 10 mg/plate
REFERENCE :
   SAIGBL Sangyo Igaku.  Japanese Journal of Industrial Health.  (Nippon Sangyo
   Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160,
   Japan)  V.1-    1959-  Volume(issue)/page/year: 27,400,19

TYPE OF TEST

{hazar

其他信息

  • 用途七:肝功能试验中配制麝香草酚浊度液，检定和测定物铋、铁、锰、钴、钍、铂和镁，检定锂、铁氰化物溴化物和碘化物，测定铜、铀、铍、碲等，气相色谱固定液(最高使用温度180℃，溶剂为氯仿)。
  • {Chemicalbo
  • 升华点:263-295 °C
  • Sigma Aldrich:100-97-0(sigmaaldrich)
  • 用途四:抗微生物剂。
  • MOL 文件:100-97-0.mol
  • TCI Shanghai:六次甲基四胺 Hexamethylenetetramine,>;99.0%(T)(100-97-0)
  • F:9-23
  • 下游产品:地西泮 --> 4-叔-丁基苄胺 --> 防垢剂 --> 2，5-二氯硫代苯-3-碳酰氯 --> 4-辛基苯甲醛 --> 4-氰基苯甲醛 --> 2,6-二甲基-1,4-二氢-3,5-吡啶二羧酸二乙酯 --> DL-氨基己内酰胺 --> 4-溴-2-氯乙酰苯胺 --> 对氯苄胺 --> 2,5-二氯-3-噻吩甲酸 --> 4-溴-3-氯乙酰苯胺 --> 啶虫脒 --> 硝西泮 --> 艾司唑仑 --> 阻垢剂 TETHMP,三乙四胺六甲叉磷酸 --> 7-氯-1,3-二氢-5-苯基-2H-1,4-苯并二氮杂-2-硫酮 --> 5-甲酰水杨酸 --> 2,6-二甲酰-4-甲基苯酚 --> 去甲西泮 --> 氨基模塑料 --> N,N-二乙基-4-氨基苯甲醛 --> 双(三甲基硅基)过氧化物 --> 甲基紫罗兰酮 --> 3-苯基-5,6-苯并香豆素 --> 可逆示温涂料(IV) --> 发泡剂H --> 4-异丙基苯甲醛 --> PTE-S无氰镀锌光亮剂 --> Α-溴代-4-硝基苯乙酮六次甲基四胺 --> 中长纤维整理剂 KB -->
  • 方法三:由甲醛和氨缩合制得。将甲醛溶液置于反应器中，通氨，在碱性溶液中进行缩合反应，反应温度保持在50-70℃，料液经冷却进入液膜真空蒸发器，于60-80℃下蒸发，使其浓度从24%提高到38%-42%，然后将反应液过滤，经真空蒸发结晶，抽滤干燥即得成品乌洛托品。
  • 用途三:用作分析试剂及硫化促进剂
  • 常规方法:本品内用聚乙烯薄膜塑料袋、外用聚丙烯纤维编织袋包装，每袋净重25kg。袋上应注明防火防潮标志。应贮存于干燥、清洁、通风的仓库内，不得露天堆放。避免受潮、污染。
  • 用途一:用用作树脂和塑料的固化剂、橡胶的硫化促进剂（促进剂H）、纺织品的防缩剂，并用于制杀菌剂、炸药等。药用时，内服后遇酸性尿分解产生甲醛而起杀菌作用，用于轻度尿路感染；外用于治癣、止汗、治腋臭。与烧碱和苯酚钠混合，用于防毒面具作光气吸收剂。
  • 图谱信息:乌洛托品(100-97-0)核磁图( 1 HNMR) 乌洛托品(100-97-0)红
  • Acros Organics:乌洛托品/六次甲基四胺 Hexamethylenetetramine, contains an anticaking agent, 98.50%(100-97-0)
  • 用途六:六亚甲基四胺主要用作树脂和塑料的固化剂、氨基塑料的催化剂和发泡剂、橡胶硫化的促进剂（促进剂H）、纺织品的防缩剂等。六亚甲基四胺是有机合成的原料，在医药工业中用来生产氯霉素。六亚甲基四胺可用作泌尿系统的消毒剂，其本身无抗菌作用，对革兰氏阴性细菌有效。其20%的溶液可用于治疗腋臭、汗脚、体癣等。它与氢氧化钠和苯酚钠混合，可做防毒面具中的光气吸收剂。并用于制造农药杀虫剂。六亚甲基四胺与发烟硝酸作用，可制得爆炸性极强的旋风炸药，简称RDX。六亚甲基四胺还可作为测定铋、铟、锰、钴、钍、铂、镁产、锂、铜、铀、铍、碲、溴化物、碘化物等的试剂和色谱分析试剂等。
  • 蒸气压:<;0.01 mm Hg ( 20 °C)
  • 外观性质:白色细粒状结晶，味初甜后苦。
  • 可燃。如超过此熔点即升华并分解，但不熔融。升温至300℃时放出氰化氢，温度再升高时，则分解为甲烷、氢和氮。几乎无臭，味甜而苦。可溶于水和氯仿，难溶于四氯化碳、丙酮、苯和乙醚，不溶于石油醚。在弱酸溶液中分解为氨及甲醛。与火焰接触时，立即燃烧并产生无烟火焰。有挥发性.
  • MSDS

系列性分类

  1. Application Areas 应用领域分类
  2. Drug Discovery 新药研发
  3. Pharmacopoeia 药典
  4. Pharmacopoeia A-Z - Pharmacopoeia
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Others 其他杂环
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Others 其他杂环
  5. N-Containing - Others
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Polyamines - Nitrogen Compounds
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Reagents
  3. Analytical Reagents for General Use - Analytical Reagents
  4. Puriss p.a. - Analytical Reagents for General Use
  5. E-H, Puriss p.a. - Puriss p.a.
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Oximes
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Amination
  1. Analytical & Chromatography 分析化学与色谱
  2. Adsorbents, Filter Aids and Drying Agents
  3. Other Drying Agents
  1. Functional Group 官能团索引
  2. aminal